{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T19:08:43Z","timestamp":1781550523172,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["301967\/2022\u20109"],"award-info":[{"award-number":["301967\/2022\u20109"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiotherapy Res Intl"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Although peak oxygen uptake (VO<jats:sub>2peak<\/jats:sub>) is one of the most important measures in clinical practice, the high cost and time consumption have led to the search for simpler devices and the development of the estimating cardiopulmonary fitness (eCPF) equation. Since the lungs are one of the sites most affected by rheumatoid arthritis (RA), this study aimed to create a predictive equation for VO<jats:sub>2peak<\/jats:sub> obtained by simple sampling technology in women with RA\u2010associated interstitial lung disease (RA\u2010ILD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study evaluated 47 women with RA\u2010ILD. The participants underwent the following evaluations: computed tomography (CT); evaluation of disease activity through the Clinical Disease Activity Index (CDAI); measurement of physical function using the Health Assessment Questionnaire disability index (HAQ\u2010DI); pulmonary function testing, including spirometry, diffusing capacity for carbon monoxide (D<jats:sc>l<\/jats:sc><jats:sub>CO<\/jats:sub>), nitrogen single\u2010breath washout (N<jats:sub>2<\/jats:sub>SBW) test, and impulse oscillometry; and cardiopulmonary exercise testing (CPET) using FitMate\u2122.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VO<jats:sub>2peak<\/jats:sub> was correlated with age (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.550, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), rheumatoid factor (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.443, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), anti\u2010cyclic citrullinated peptide antibodies (<jats:italic>r<\/jats:italic>\u00a0= \u22120.410, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004), CDAI (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.462, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), HAD\u2010DI (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.486, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0005), forced vital capacity (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.491, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0004), D<jats:sc>l<\/jats:sc><jats:sub>CO<\/jats:sub> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.621, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), phase III slope of N<jats:sub>2<\/jats:sub>SBW (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.647, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), resonance frequency (<jats:italic>F<\/jats:italic><jats:sub>res<\/jats:sub>, <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.717, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), integrated low\u2010frequency reactance (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.535, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0001), and the inhomogeneity of respiratory system resistance between 4 and 20\u00a0Hz (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.631, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). In the CT examination, patients with extensive ILD had significantly lower VO<jats:sub>2peak<\/jats:sub> than patients with limited ILD (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). In the stepwise forward regression analysis, <jats:italic>F<\/jats:italic><jats:sub>res<\/jats:sub>, D<jats:sc>l<\/jats:sc><jats:sub>CO<\/jats:sub> and age explained 61% of the VO<jats:sub>2peak<\/jats:sub> variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As assessed by CPET, women with RA\u2010ILD show reduced cardiopulmonary fitness, which can be explained at least in part by the presence of small airway disease, deterioration of pulmonary gas exchange, and advanced age. These associations of pulmonary variables with eCPF may be clinically important and support the use of the eCPF equation to improve patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pri.2005","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T15:09:15Z","timestamp":1680793755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Estimating cardiopulmonary fitness with a new sampling technology in patients with rheumatoid arthritis\u2010associated interstitial lung disease"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7971-5338","authenticated-orcid":false,"given":"Rafael Alexandre de Oliveira","family":"Deucher","sequence":"first","affiliation":[{"name":"Rehabilitation Sciences Post\u2010Graduation Programme Augusto Motta University Centre (UNISUAM)  Rio de Janeiro 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