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This scoping review explores its use in managing fatigue among various neurological conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A thorough literature search was carried out using PubMed, Scopus, CINAHL, Web of Science, Embase, ProQuest, and the Cochrane Library. Google Scholar and clinicaltrials.gov were manually searched for gray literature and ongoing trials, respectively. Regardless of the study design, all studies utilizing tDCS for the management of fatigue in various neurological conditions were considered. Two reviewers independently screened all the studies, following which the data were retrieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Studies employing tDCS for fatigue management across neurological conditions is as follows: Multiple sclerosis (MS) (<jats:italic>n<\/jats:italic>\u00a0=\u00a028, 66%), stroke (<jats:italic>n<\/jats:italic>\u00a0=\u00a05, 12%), Parkinson's disease (PD) (<jats:italic>n<\/jats:italic>\u00a0=\u00a04, 10%), post\u2010polio syndrome (PPS) (<jats:italic>n<\/jats:italic>\u00a0=\u00a02, 5%), traumatic brain injury (TBI) (<jats:italic>n<\/jats:italic>\u00a0=\u00a02, 5%), and amyotrophic lateral sclerosis (<jats:italic>n<\/jats:italic>\u00a0=\u00a01, 2%). All the studies used anodal stimulation, with the common stimulation site being the left dorsolateral prefrontal cortex for MS, stroke, and PD. A stimulation intensity of 1.0\u20134.0\u00a0mA with a duration ranging from 15 to 30\u00a0min in 1 to 24 sessions were commonly reported. The Fatigue Severity Scale (<jats:italic>n<\/jats:italic>\u00a0=\u00a021) and Modified Fatigue Impact Scale (<jats:italic>n<\/jats:italic>\u00a0=\u00a017) were frequently implemented outcome measures. Regardless of the study design, 36\/42 (85.7%) studies reported an improvement in fatigue scores in the tDCS group. The common adverse events noted were tingling (<jats:italic>n<\/jats:italic>\u00a0=\u00a08, 35%), headache (<jats:italic>n<\/jats:italic>\u00a0=\u00a06, 26%), and itching (<jats:italic>n<\/jats:italic>\u00a0=\u00a06, 26%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Application of tDCS for fatigue was explored in individuals with stroke, PD, PPS, and TBI after MS. Even though a wide range of treatment parameters and outcome measures were adopted to assess and target fatigue, tDCS proves to have a promising role in alleviating this symptom.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pri.2054","type":"journal-article","created":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T17:19:28Z","timestamp":1697390368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Transcranial direct current stimulation for fatigue in neurological conditions: A systematic scoping review"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9201-9419","authenticated-orcid":false,"given":"Akhila","family":"Jagadish","sequence":"first","affiliation":[{"name":"Department of Physiotherapy Manipal College of Health Professions Manipal Academy of Higher Education  Manipal Karnataka India"},{"name":"Centre for Comprehensive Stroke Rehabilitation and Research (CCSRR) Manipal College of Health Professions Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0305-535X","authenticated-orcid":false,"given":"Apoorva M.","family":"Shankaranarayana","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Manipal College of Health Professions Manipal Academy of Higher Education  Manipal Karnataka India"},{"name":"Centre for Comprehensive Stroke Rehabilitation and Research (CCSRR) Manipal College of Health Professions Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-5748","authenticated-orcid":false,"given":"Manikandan","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Manipal College of Health Professions Manipal Academy of Higher Education  Manipal Karnataka India"},{"name":"Centre for Comprehensive Stroke Rehabilitation and Research (CCSRR) Manipal College of Health Professions Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0828-6977","authenticated-orcid":false,"given":"John M.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Manipal College of Health Professions Manipal Academy of Higher Education  Manipal Karnataka India"},{"name":"Centre for Comprehensive Stroke Rehabilitation and Research (CCSRR) Manipal College of Health Professions Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3233\/rnn\u2010130321"},{"key":"e_1_2_10_3_1","unstructured":"Acler M. 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