{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:27:25Z","timestamp":1784204845766,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiotherapy Res Intl"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Vulvovaginal Candidiasis (VVC) is a prevalent genital infection in women of reproductive age and requires effective non\u2010drug therapies. Therefore, this study aimed to investigate the effect of blue light emitting diode (LED) therapy as an alternative treatment for recurrent VVC due to its proven antimicrobial properties. The safety and non\u2010invasiveness of LED therapy make it a promising option for sensitive tissue applications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This randomized controlled trial recruited 60 women with culture\u2010confirmed VVC. Participants were randomly allocated to two groups. Group A (control group) received standard antifungal treatment with Gynoconazol 0.8% vaginal cream for three consecutive nights (n\u00a0=\u00a030). Group B (study group) received the same antifungal treatment plus two 60\u2010min sessions of blue LED therapy directed at the vagina and vulva, with the sessions separated by two days (n\u00a0=\u00a030). Candida count (via CHROMagar\u2122 Candida) and vaginal pH (via AD110\u2010AD111\u00a0m) were assessed at baseline and one week after initiating treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Post\u2010treatment, group (B) demonstrated a significantly greater reduction in Candida count compared to group (A) (mean difference (MD) 8.267; 95% Confidence Interval (CI) 6.723\u20139.811; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0001). However, there was no statistically significant difference in vaginal pH between the groups (MD \u22120.03; 95% CI \u22120.244\u20130.178; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.749).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Blue LED therapy effectively reduces Candida count in women with recurrent VVC without adversely affecting the vaginal pH, highlighting its safety and efficacy as a treatment modality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pri.2129","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T06:50:03Z","timestamp":1725346203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of blue light emitting diode therapy on recurrent vulvovaginal candidiasis: A randomized assessor\u2010blinded controlled trial"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7506-7299","authenticated-orcid":false,"given":"Radwa M.","family":"Shalaby","sequence":"first","affiliation":[{"name":"Faculty of Physical Therapy Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2497-3845","authenticated-orcid":false,"given":"Soheir M.","family":"El\u2010Kosery","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy for Women's Health Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3268-7412","authenticated-orcid":false,"given":"Mahmoud M.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9918-7634","authenticated-orcid":false,"given":"Doaa A.","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy for Women's Health Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.explore.2023.04.005"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9030500"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i23.6839"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010019\u201001127\u20108"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12934\u2010020\u201001464\u20104"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.1993.2.189"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105545.161483"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05025\u201011"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010017\u20102228\u20104"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/7834474"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.497972"},{"issue":"3","key":"e_1_2_15_13_1","first-page":"354","article-title":"Evaluation of vaginal pH for detection of bacterial vaginosis","volume":"138","author":"Hemalatha R.","year":"2013","journal-title":"Indian Journal of Medical Research"},{"issue":"2","key":"e_1_2_15_14_1","first-page":"76","article-title":"Evaluating vaginal pH. 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