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However, the effectiveness of combining RAT\u2010UL with other therapeutic approaches remains unclear. This systematic review and meta\u2010analysis, registered in PROSPERO (CRD42023422583), aimed to investigate the effect of combination therapy added to RAT\u2010UL compared with RAT\u2010UL alone on improving the motor function, and capacity of the affected upper limb and activity of daily living.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was conducted in PubMed, CINAHL, Physiotherapy Evidence Database (PEDro), and Web of Science. We included randomized controlled trials (RCTs) published in English before October 2024. Methodological quality was assessed using the Cochrane risk of bias tool for RCTs. Meta\u2010analysis was performed using RevMan 5.4 software. The primary inclusion criteria encompassed adults after stroke who underwent combining RAT\u2010UL with other therapeutic approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After reviewing 5669 studies, we included 16 RCTs in this study. The overall effect of combining RAT\u2010UL with other therapeutic approaches on the motor function in Fugl\u2010Meyer Assessment was not significant improvement (MD\u00a0=\u00a01.40; 95% CI, 0.00\u20132.81; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.05), whereas the differences on capacity of upper limb in Wolf Motor Function Test\u2014Performance Time (MD\u00a0=\u00a00.48; 95% CI, 0.01\u20130.94; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04) and activities of daily living in the Functional Independence Measure were also observed (MD\u00a0=\u00a02.21; 95% CI, 0.12\u20134.31; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). However, no significant differences were found in the analysis of activity levels in the ICF domains (SMD\u00a0=\u00a00.50; 95% CI, \u22121.33\u20132.34; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.08). Subgroup analyses showed significant improvements in motor function in the Fugl\u2010Meyer Assessment when partial substitution of RAT\u2010UL with other high\u2010intensity therapeutic approaches (MD\u00a0=\u00a03.42; 95% CI, 0.61\u20136.24; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Adding a high\u2010intensity therapeutic approach to RAT\u2010UL may lead to improvement in upper limb function and capacity compared with RAT\u2010UL alone. However, the effectiveness of combining RAT\u2010UL with other therapeutic approaches appears to vary depending on the type of adjunctive therapy employed. The effect sizes were small, and the findings across studies were inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>PROSPERO (CRD42023422583).<\/jats:p><\/jats:sec>","DOI":"10.1002\/pri.70091","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T04:28:51Z","timestamp":1753158531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Combining Robotic Assisted Therapy for Upper Limb With Other Therapeutic Approaches After Stroke: A Systematic Review and Meta\u2010Analysis of Randomized Control Trials"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8388-9815","authenticated-orcid":false,"given":"Naoya","family":"Anmoto","sequence":"first","affiliation":[{"name":"Division of Occupational Therapy, Department of Rehabilitation Medicine Nagoya City University Rehabilitation Hospital  Nagoya 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