{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:58:07Z","timestamp":1761663487399,"version":"build-2065373602"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3602603"],"award-info":[{"award-number":["2022YFC3602603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiotherapy Res Intl"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to examine the effect of home\u2010based pulmonary rehabilitation (PR) on bone mineral density (BMD), lung function, dyspnea, and walking ability for stable Chronic Obstructive Pulmonary Disease (COPD) patients with OP (osteoporosis).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The required sample size was 27 per group, adjusted to 32 per group to account for a 15% dropout rate, ensuring 90% power. This is a 6\u2010month randomized, single\u2010blind, controlled trial. COPD patients with OP were randomly divided into the home\u2010based PR and control groups. Patients in the control group received the program of health education and drug treatment. Patients in the home\u2010based PR group received additional home\u2010based PR programs. The primary outcome was the bone mineral density (BMD) at the lumbar spine. The secondary outcomes included BMD at the femoral neck, lung function (FEV\n                      <jats:sub>1<\/jats:sub>\n                      % and FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC), the modified Medical Research Council (mMRC), COPD assessment test (CAT), Borg dyspnea scale (Borg), and Six\u2010minute walk distance test (6MWT). All outcomes were assessed at 3 and 6\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 6\u00a0months, 29 patients in the home\u2010based PR group and 28 in the control group completed the trial. The BMD of the lumbar spine and femoral neck in the home\u2010based PR group was significantly higher than that in the control group (0.758\u00a0\u00b1\u00a00.048 vs. 0.728\u00a0\u00b1\u00a00.057,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.031, 0.670\u00a0\u00b1\u00a00.024 vs. 0.658\u00a0\u00b1\u00a00.019,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.039, respectively). There was no significant difference in FEV\n                      <jats:sub>1<\/jats:sub>\n                      % and FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC between the groups. The mMRC, CAT, and Borg of the home\u2010based PR group were significantly lower than those of the control group at 3 and 6\u00a0months (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). The 6MWT of the home\u2010based PR group was significantly higher than that of the control group at 3 and 6\u00a0months (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Home\u2010based PR improved BMD, dyspnea, symptoms, function, and daily living ability but not lung function in COPD patients with OP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pri.70097","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T05:29:16Z","timestamp":1754458156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Home\u2010Based Pulmonary Rehabilitation Management on Bone Mineral Density and Function for Stable Chronic Obstructive Pulmonary Disease Patients With Osteoporosis: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"30","author":[{"given":"Kexin","family":"Wang","sequence":"first","affiliation":[{"name":"School of Rehabilitation Sciences West China School of Medicine West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Rehabilitation Medicine Rehabilitation Medicine Center West China Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Rehabilitation Medicine West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The Sixth People\u2019s Hospital of Chengdu  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Ren","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Sciences West China School of Medicine West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Rehabilitation Medicine Rehabilitation Medicine Center West China Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Rehabilitation Medicine West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5349-0571","authenticated-orcid":false,"given":"Chengqi","family":"He","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Sciences West China School of Medicine West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Rehabilitation Medicine Rehabilitation Medicine Center West China Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Rehabilitation Medicine West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9656-7225","authenticated-orcid":false,"given":"Chengsen","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Sciences West China School of Medicine West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Rehabilitation Medicine Rehabilitation Medicine Center West China Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Rehabilitation Medicine West China Hospital Sichuan University  Chengdu 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