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Although post\u2010tuberculosis lung disease (PTLD) is a growing concern worldwide due to poor physical functioning, little is known about peripheral muscle dysfunction. Therefore, the objective of this study was to evaluate patient performance during the Glittre Activities of Daily Living Test (TGlittre) and assess its association with muscle function, lung function, and HRQoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 47 patients with PTLD who underwent the TGlittre. We also assessed patients for respiratory muscle strength, handgrip strength (HGS), quadriceps muscle strength (QMS), and HRQoL using the Medical Outcomes Study 36\u2010Item Short\u2010Form Health Survey (SF\u201036).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HGS and QMS were reduced in 34% and 25.5% of participants, respectively. Spirometry showed an obstructive pattern, a restrictive pattern, and a normal pattern in 46.8%, 31.9% and 21.3% of participants, respectively, while 42.6% of them had reduced diffusion capacity of lung for carbon monoxide (DLCO). The median TGlittre time was 4.43 (3.48\u20134.96) minutes, about 15% longer than the expected time to complete it. There was a significant correlation between TGlittre time and DLCO (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>s<\/jats:italic>\n                      <\/jats:sub>\n                      \u00a0=\u00a0\u22120.532,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0002), maximum inspiratory pressure (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>s<\/jats:italic>\n                      <\/jats:sub>\n                      \u00a0=\u00a0\u22120.407,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005), maximum expiratory pressure (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u00a0=\u00a0\u22120.382,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.008), HGS (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>s<\/jats:italic>\n                      <\/jats:sub>\n                      \u00a0=\u00a0\u22120.327,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.024), QMS (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>s<\/jats:italic>\n                      <\/jats:sub>\n                      \u00a0=\u00a0\u22120.314,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.031), and various SF\u201036 domains. In the regression analysis, DLCO, QMS, and HGS explained 39% of the variability in TGlittre time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>PTLD significantly impacts functional capacity, as determined by TGlittre. These patients have muscle dysfunction, deteriorated HRQoL, and impaired lung function. Impaired lung diffusion and reduced peripheral muscle strength (PMS) are independently associated with lower functional capacity. Therefore, rehabilitative strategies are crucial for improving care for this group of patients. This is the first study using the TGlittre to explore PMS in PTLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The protocol was registered on\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      with the identifier NCT06127641\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pri.70115","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T03:45:44Z","timestamp":1759376744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Peripheral Muscle Strength and Pulmonary Function Negatively Impact Functional Capacity in Patients With Post\u2010Tuberculosis Lung Disease: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4791-3646","authenticated-orcid":false,"given":"Aline Mendes Leal Rodrigues de","family":"Souza","sequence":"first","affiliation":[{"name":"Rehabilitation Sciences Post\u2010Graduation Programme Augusto Motta University Center (UNISUAM)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2660-5167","authenticated-orcid":false,"given":"Davi Luiz Olimpio da","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculty of Physiotherapy Augusto Motta University Center (UNISUAM)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4317-4636","authenticated-orcid":false,"given":"Matheus Mello da","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculty of Physiotherapy Augusto Motta University Center (UNISUAM)  Rio de 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