{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:47:39Z","timestamp":1793108859925,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiotherapy Res Intl"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Immersive virtual reality (IVR)\u2010based rehabilitation provides high\u2010intensity, engaging, task\u2010oriented training and motor exploration for upper limb (UL) recovery post\u2010stroke. However, its feasibility and dose\u2010response in acute and subacute stroke patients remain unclear. The purpose of this study was to evaluate the feasibility, safety and dose\u2010response of IVR\u2010based rehabilitation for post\u2010stroke UL recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A pilot trial included 12 acute and subacute stroke patients (mean age 59.8\u00a0\u00b1\u00a014.2\u00a0years) with upper limb impairment randomized into two groups: Group A (10 IVR sessions\u00a0+\u00a0conventional rehabilitation [CR]) and Group B (20 IVR sessions\u00a0+\u00a0CR). Feasibility outcomes included adherence, usability (User Satisfaction Evaluation Questionnaire [USEQ], System Usability Scale [SUS]), system operability, and adverse effects. Motor outcomes, categorized by the International Classification of Functioning, Disability, and Health (ICF), assessed UL impairment (Fugl\u2010Meyer Assessment, Medical Research Council scale), activity (Box and Block Test), and participation (Motor Activity Log 30). Blinded therapists conducted assessments at baseline, post\u2010intervention, and 4\u2010week follow\u2010up. Dose\u2010response was analyzed using Probability of Superiority (PS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Feasibility was high, reporting 98% adherence, favorable usability scores (USEQ: 81.6\u00a0\u00b1\u00a015; SUS: 77.5\u00a0\u00b1\u00a07.4), efficient setup time (5.14\u00a0\u00b1\u00a01.57\u00a0min), system stability (77.86\u00a0\u00b1\u00a06.78%) and no severe adverse effects. Clinically meaningful motor improvements were observed across all ICF domains in both groups. Although the sample size was insufficient for inferential testing, descriptive trends and PS values above 75% suggested a potential dose\u2010response trend favoring higher IVR exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>IVR\u2010based rehabilitation showed high feasibility, safety, and improvements in motor recovery, with a dose\u2010response trend favoring higher doses. These findings align with evidence that IVR enhances neuroplasticity\u2010driven recovery through high\u2010intensity, engaging, exploratory, and task\u2010oriented upper limb training. Despite the small sample and brief follow\u2010up, this study provides key data to guide larger trials on efficacy and optimal dosing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT07086365\">https:\/\/clinicaltrials.gov\/study\/NCT07086365<\/jats:ext-link>\n                      , NCT07086365\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pri.70151","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T11:05:18Z","timestamp":1766142318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Immersive Virtual Reality\u2010Based Rehabilitation for Upper Limb Recovery in Acute and Subacute Stroke Patients: A\u00a0Feasibility Study"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0001-6104","authenticated-orcid":false,"given":"Benjam\u00edn","family":"Peralta\u2010Wieland","sequence":"first","affiliation":[{"name":"Research Unit Neuro Group XR Inc.  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