{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:31:39Z","timestamp":1793363499778,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["404976\/2023\u20109"],"award-info":[{"award-number":["404976\/2023\u20109"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiotherapy Res Intl"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Chronic Obstructive Pulmonary Disease (COPD) is a pulmonary condition characterized by airflow obstruction, which progresses with systemic alterations such as changes in muscle composition and metabolism, anticipating the activation of the inspiratory metaboreflex. This study aimed to analyze the acute effects of Inspiratory Muscle Training (IMT) on peripheral muscle metabolism in individuals with COPD, using near\u2010infrared spectroscopy (NIRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized, blinded, crossover study included 29 individuals with COPD who underwent three distinct sessions: high\u2010load IMT (IMT\u2010Strength, 60% of maximal inspiratory pressure\u2014MIP), low\u2010load IMT (IMT\u2010Endurance, 30% of MIP), and a sham protocol. Tissue oxygenation of the gastrocnemius muscle was assessed using NIRS before and after each protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Differences in mean final tissue oxygen saturation were observed only during the IMT\u2010Endurance protocol. The oxygen desaturation time was shorter during the IMT\u2010Strength protocol compared with the other groups. Although not statistically significant, patients with more severe COPD (GOLD 3\u20134) exhibited an oxygen desaturation rate higher during the strength IMT compared with the endurance and sham protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acute high\u2010intensity IMT may accentuate the reduction in peripheral perfusion, especially in patients with advanced COPD, suggesting possible metaboreflex activation. Conversely, endurance IMT may improve peripheral perfusion. These findings reinforce the need for careful and individualized prescription of IMT in the COPD population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      Clinical Trials number: NCT 06827379\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT06827379\">https:\/\/clinicaltrials.gov\/study\/NCT06827379<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pri.70177","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:28:17Z","timestamp":1772962097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute Effect of Inspiratory Muscle Training on Peripheral Tissue Oxygenation Behavior in Individuals With COPD: A Randomized Crossover Study"],"prefix":"10.1002","volume":"31","author":[{"given":"Nat\u00e1lia Mota da Silva","family":"Borges","sequence":"first","affiliation":[{"name":"Postgraduate Program in Physical Therapy Universidade Federal da Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dyego Tavares de","family":"Lima","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Physical Therapy Universidade Federal da Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur Bruno de Abreu","family":"Morais","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Universidade Federal da Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Nat\u00e1lia Freitas Cavalcante","family":"Ten\u00f3rio","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Universidade Federal da Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandyelle Teixeira","family":"Vieira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Physical Therapy Universidade Federal da Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hellen Maria Lacerda de Oliveira","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Physical Therapy Universidade Federal da Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annicia Lins","family":"Freitas","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Physical Therapy Universidade Federal da Para\u00edba  Jo\u00e3o Pessoa Para\u00edba 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