{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:10:13Z","timestamp":1786122613210,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiotherapy Res Intl"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson's disease is a neurological condition with motor and non\u2010motor symptoms that negatively affect well\u2010being and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review aimed to analyze the effects of resistance training on quality of life in individuals with Parkinson's disease and to summarize recommendations for clinical application.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>\n                      Following PRISMA recommendations, searches were conducted in Web of Science, PubMed, EMBASE (with\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      ), PEDro, CINAHL, and Scopus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection<\/jats:title>\n                    <jats:p>RCTs were included that compared the effects of resistance training with other therapeutic modalities or a control group on the quality of life in people with Parkinson's.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction and Synthesis<\/jats:title>\n                    <jats:p>Data were extracted using Microsoft Excel and analyzed in RevMan. The risk of bias was assessed using the RoB 2 tool, the protocol reporting completeness was evaluated using CERT and certainty of the evidence was rated using GRADE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fourteen studies were included, featuring highly heterogeneous protocols. Resistance training was superior to control (SMD \u22120.81; CI \u22121.45 to \u22120.18;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      88%; moderate certainty of the evidence), although no significant difference was found compared to other therapeutic modalities (SMD \u22120.02; CI \u22120.44 to 0.41; low certainty of the evidence). Exploratory subgroup analyses suggested a trend toward more favorable results in trials lasting longer than 12\u00a0weeks, involving patients with mild\u2010to\u2010moderate disease severity (H&amp;Y\u00a0\u2264\u00a03), and reporting high protocol completeness (CERT\u00a0&gt;\u00a011). Most of the studies were classified as having a low risk of bias and presented a moderate description of the protocols in the CERT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>The included studies exhibited high heterogeneity and required data imputation for missing standard deviations. Additionally, exploratory subgroup analyses were underpowered due to the limited number of trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Current evidence suggests that resistance training may improve quality of life in individuals with Parkinson's disease. Exploratory subgroup analyses tentatively suggest potential trends favoring mild\u2010to\u2010moderate stages and intervention exceeding 12\u00a0weeks, while being a safe practice. However, high heterogeneity limits the certainty of the evidence. Future studies should prioritize standardized reporting (CERT) to ensure intervention reproducibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>PROSPERO record (CRD42024588780)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pri.70266","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:16:14Z","timestamp":1782731774000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does Resistance Training Improve the Quality of Life of\u00a0People With Parkinson's Disease? Evidence and\u00a0Recommendations for Clinical Application Through a Systematic Review and Meta\u2010Analysis of\u00a0Randomized Clinical Trials"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-6481","authenticated-orcid":false,"given":"Loiane Cristina","family":"de Souza","sequence":"first","affiliation":[{"name":"Department of Physical Education Santa Catarina State University\u2014UDESC  Florian\u00f3polis Brazil"},{"name":"Department of Physiotherapy Santa Catarina State University\u2014UDESC  Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz","family":"Senna","sequence":"additional","affiliation":[{"name":"Department of Physical Education Santa Catarina State University\u2014UDESC  Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson","family":"D'Oliveira","sequence":"additional","affiliation":[{"name":"Department of Physical Education Santa Catarina State University\u2014UDESC  Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubia","family":"Truppel","sequence":"additional","affiliation":[{"name":"Department of Physical Education Santa Catarina State University\u2014UDESC  Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Torres","family":"Vilarino","sequence":"additional","affiliation":[{"name":"Department of Physical Education Santa Catarina State University\u2014UDESC  Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6640-9314","authenticated-orcid":false,"given":"Alexandro","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Physical Education Santa Catarina State University\u2014UDESC  Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010022\u201005140\u20101"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2018.09.032"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000782"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.34024\/RNC.2005.V13.8827"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAMDA.2012.11.012"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/BJSPORTS\u20102020\u2010102955"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004\u2010282X\u2010ANP\u20102020\u20100285"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955\u2010017\u20100742\u20105"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.110740"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.25380"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11332\u2010021\u201000825\u20109"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13528"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.23736\/S1973\u20109087.16.04272\u20106"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JSHS.2020.06.003"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.828495"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013856.PUB2\/MEDIA\/CDSR\/CD013856\/IMAGE_N\/NCD013856\u2010FIG\u201019"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004\u2010282X20180071"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318213fefb"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/CSHPERSPECT.A008862"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.21922"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11556\u2010019\u20100217\u20102"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604.ch8"},{"key":"e_1_2_12_24_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5","author":"Higgins J. P. T.","year":"2024"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455863"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/AGEING\/26.5.353"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.0534"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CCA.2021.08.009"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.25787"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.591605"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1601080"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1836\u20109553(13)70141\u20103"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007733"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.23462"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968314565511"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphys.2017.02.015"},{"key":"e_1_2_12_37_1","volume-title":"The GRADE Book Version 1","author":"Neumann I.","year":"2024"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.N160"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.22782"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8110529"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353\u20108020(09)70831\u20104"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S131903"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30295\u20103"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.23736\/S1973\u20109087.17.04572\u20105"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NRLENG.2023.04.008"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140584"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2019.07.006"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845\u2010019\u201002038\u2010z"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000945"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CGER.2019.08.002"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports\u20102016\u2010096651"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1980\u20106574201800020004"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000004025"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010021\u201005738\u2010z"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845\u2010022\u201003205\u20105"}],"container-title":["Physiotherapy Research International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pri.70266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pri.70266","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pri.70266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T11:32:06Z","timestamp":1786102326000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pri.70266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/pri.70266"],"URL":"https:\/\/doi.org\/10.1002\/pri.70266","archive":["Portico"],"relation":{},"ISSN":["1358-2267","1471-2865"],"issn-type":[{"value":"1358-2267","type":"print"},{"value":"1471-2865","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"2025-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70266"}}