{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:30:28Z","timestamp":1787056228039,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiotherapy Res Intl"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Leukemias, lymphomas, and central nervous system tumors are among the most common pediatric cancers and may lead to motor deficits, impaired balance, reduced muscle strength, fatigue, and decreased functional capacity. Early physiotherapy during hospitalization may help prevent inactivity and support functional preservation in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effects of a therapeutic exercise program on quality of life, muscle strength, fatigue, and functional capacity in hospitalized pediatric oncohematological patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty participants aged 8\u201317\u00a0years with oncohematological diseases were randomized to an intervention group (IG) or a minimal active physiotherapy comparator group (CG). Assessments included the 6\u2010min walk test, handgrip dynamometry, the PedsQL Multidimensional Fatigue Scale, and the PedsQL Cancer Module at admission and discharge. The IG performed daily 25\u2010min supervised sessions including aerobic, resistance, and breathing exercises with ambulation guidance, whereas the CG received breathing exercises and ambulation guidance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant group\u00a0\u00d7\u00a0time interactions were observed for total fatigue or its domains, overall quality of life or its assessed domains, handgrip strength, or six\u2010minute walk test distance. Time\u2010related changes were observed for some outcomes, but these occurred without evidence of differential change between groups and were not interpreted as effects of the structured exercise protocol. No intervention\u2010related adverse events requiring permanent protocol discontinuation were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The structured in\u2010hospital therapeutic exercise protocol could be delivered under close clinical supervision without recorded intervention\u2010related adverse events requiring permanent discontinuation. However, the structured protocol did not demonstrate superiority over the minimal active physiotherapy comparator for fatigue, quality of life, muscle strength, or functional capacity. These findings should be interpreted cautiously because of the small sample size, clinical heterogeneity, variable intervention exposure, and limited intervention\u2010fidelity data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Brazilian Registry of Clinical Trials (ReBEC), RBR\u20108sxnfyd<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pri.70324","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:01:41Z","timestamp":1787054501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Exercise Protocol During Hospitalization in Pediatric Oncohematological Patients: Randomized Clinical Trial"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8999-6152","authenticated-orcid":false,"given":"Cintia Freire","family":"Carniel","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Delineamento de Estudos e Escrita Cient\u00edfica Centro Universit\u00e1rio FMABC  Santo Andr\u00e9 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7464-1500","authenticated-orcid":false,"given":"Bruna Cunha de","family":"Souza","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Delineamento de Estudos e Escrita Cient\u00edfica Centro Universit\u00e1rio FMABC  Santo Andr\u00e9 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6216-1031","authenticated-orcid":false,"given":"Henrique Ferreira","family":"Leite","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Delineamento de Estudos e Escrita Cient\u00edfica Centro Universit\u00e1rio FMABC  Santo Andr\u00e9 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6692-4810","authenticated-orcid":false,"given":"Juliana","family":"Zangirolami\u2010Raimundo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Delineamento de Estudos e Escrita Cient\u00edfica Centro Universit\u00e1rio FMABC  Santo Andr\u00e9 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3043-0728","authenticated-orcid":false,"given":"Rodrigo Daminello","family":"Raimundo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Delineamento de Estudos e Escrita Cient\u00edfica Centro Universit\u00e1rio FMABC  Santo Andr\u00e9 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzab130"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008796.pub3"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon\u20102023\u20100189"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14796694.2024.2429942"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2576"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102214.2003.00318.x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/mph.0000000000000101"},{"key":"e_1_2_13_10_1","unstructured":"INSTITUTO NACIONAL DE C\u00c2NCER JOS\u00c9 ALENCAR GOMES DA SILVA.C\u00e2ncer infantojuvenil. 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