{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:06:51Z","timestamp":1788941211712,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiotherapy Res Intl"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Prolonged weaning\u2014characterized by failure in three consecutive spontaneous breathing trials (SBTs) and requiring over 7\u00a0days of mechanical ventilation post\u2010initial SBT\u2014presents a critical clinical challenge often exacerbated by intensive care unit\u2010acquired weakness (ICU\u2010AW) and impaired airway clearance. Mobilization and chest physiotherapy (CPT) are promising therapeutic strategies. This study evaluated the association between a combined mobilization and CPT protocol and weaning outcomes in subjects requiring prolonged mechanical ventilation using a retrospective historical control design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study analyzed 202 subjects who need a requirement for prolonged mechanical ventilation exceeding 21\u00a0days admitted to Respiratory Care Center (RCC). Outcomes were compared between a historical control cohort (2018\/01\/01\u20132020\/01\/01;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0100), which received standard medical care without mobilization or CPT, and an intervention cohort (2020\/01\/01\u20132022\/03\/01;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0102), which received the combined protocol. The primary outcome was occurrence of weaning failure; the secondary outcome was RCC mortality occurrence. Multivariable logistic regression was performed to determine independent predictors of weaning failure occurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariable logistic regression demonstrated that receiving mobilization and CPT was independently associated with lower weaning failure occurrence (OR 0.22, 95% CI [0.10, 0.49],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and Acute Physiology and Chronic Health Evaluation II (OR 1.08, 95% CI [1.01, 1.15],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.018) were also associated with higher weaning occurrence, whereas age (OR 1.02, 95% CI [0.99, 1.02],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.174) and GCS (OR 1.03, 95% CI [0.95, 1.11],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.442) were not. No significant difference was detected in RCC mortality occurrence with non\u2010adjusted comparison (OR 1.58, 95% CI [0.54\u20134.63],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.398).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Receiving mobilization and CPT was independently associated with lower odds of weaning failure occurrence in RCC, likely due to improved pulmonary hygiene and reduced ICU\u2010acquired weakness. RCC mortality occurrence did not differ between groups, supporting safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pri.70337","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T07:30:08Z","timestamp":1788939008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Mobilization and Chest Physiotherapy on Weaning Outcome of Prolonged Weaning Subjects: A Retrospective Cohort"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-1131","authenticated-orcid":false,"given":"Tsung\u2010Hsien","family":"Wang","sequence":"first","affiliation":[{"name":"School and Graduate Institute of Physical Therapy, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Department of Gerontology and Health Care Management Chang Gung University of Science and Technology  Taoyuan Taiwan"},{"name":"Department of 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