{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:23:37Z","timestamp":1758893017357},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,18]],"date-time":"2012-05-18T00:00:00Z","timestamp":1337299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Protein Science"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dengue is one of the most infectious viral diseases prevalent mainly in tropical countries. The virus is transmitted by <jats:italic>Aedes<\/jats:italic> species of mosquito, primarily <jats:italic>Aedes aegypti<\/jats:italic>. Dengue remains a challenging drug target for years as the virus eludes the immune responses. Currently, no vaccines or antiviral drugs are available for dengue prevention. Previous studies suggested that the immunosuppressive drug FK506 shows antimalarial activity, and its molecular target, FK506\u2010binding protein (FKBP), was identified in the <jats:italic>Plasmodium<\/jats:italic> parasite. Likewise, a FKBP family protein has been identified in <jats:italic>A. aegypti<\/jats:italic> (<jats:italic>Aa<\/jats:italic>FKBP12) in which <jats:italic>Aa<\/jats:italic>FKBP12 is assumed to play a similar role in its life cycle. FKBPs belong to a highly conserved class of proteins and are considered as an attractive pharmacological target. Herein, we present a high\u2010resolution crystal structure of <jats:italic>Aa<\/jats:italic>FKBP12 at 1.3 \u00c5 resolution and discuss its structural features throwing light in facilitating the design of potential antagonists against the dengue\u2010transmitting mosquito.<\/jats:p>","DOI":"10.1002\/pro.2079","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T19:08:25Z","timestamp":1334862505000},"page":"1080-1084","source":"Crossref","is-referenced-by-count":7,"title":["High\u2010resolution crystal structure of FKBP12 from <i>Aedes aegypti<\/i>"],"prefix":"10.1002","volume":"21","author":[{"given":"Sreekanth","family":"Rajan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai Qian","family":"Saw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quoc 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