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Yet the difference between apoE3, the common form, and apoE4 is a single amino acid of the 299 in this 34 kDa protein. Structure determination of the two domain full length apoE3 protein was only accomplished in 2011 and supports the notion that mutations in the N\u2010terminal domain can be propagated through the structure to the C\u2010terminal domain. Understanding the structural differences between apoE3 and apoE4 is critical for finding ways to modulate the deleterious effect of apoE4.<\/jats:p>","DOI":"10.1002\/pro.2379","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:38:53Z","timestamp":1381541933000},"page":"1820-1825","source":"Crossref","is-referenced-by-count":36,"title":["Concerning the structure of apoE"],"prefix":"10.1002","volume":"22","author":[{"given":"Carl","family":"Frieden","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biophysics Washington University School of Medicine St. Louis Missouri 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanchan","family":"Garai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biophysics Washington University School of Medicine St. Louis Missouri 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