{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:40:47Z","timestamp":1778539247749,"version":"3.51.4"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI056305"],"award-info":[{"award-number":["AI056305"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Protein Science"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The spirochete <jats:italic>Treponema pallidum<\/jats:italic> is the causative agent of syphilis, a sexually transmitted infection of major global importance. Other closely related subspecies of <jats:italic>Treponema<\/jats:italic> also are the etiological agents of the endemic treponematoses, such as yaws, pinta, and bejel. The inability of <jats:italic>T. pallidum<\/jats:italic> and its close relatives to be cultured <jats:italic>in vitro<\/jats:italic> has prompted efforts to characterize <jats:italic>T. pallidum<\/jats:italic>'s proteins structurally and biophysically, particularly those potentially relevant to treponemal membrane biology, with the goal of possibly revealing the functions of those proteins. This report describes the structure of the treponemal protein Tp0737; this polypeptide has a fold characteristic of a class of periplasmic ligand\u2010binding proteins associated with ABC\u2010type transporters. Although no ligand for the protein was observed in electron\u2010density maps, and thus the nature of the native ligand remains obscure, the structural data described herein provide a foundation for further efforts to elucidate the ligand and thus the function of this protein in <jats:italic>T. pallidum<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/pro.3133","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T08:24:35Z","timestamp":1486455875000},"page":"847-856","source":"Crossref","is-referenced-by-count":8,"title":["Functional clues from the crystal structure of an orphan periplasmic ligand\u2010binding protein from <i>Treponema pallidum<\/i>"],"prefix":"10.1002","volume":"26","author":[{"given":"Chad. A.","family":"Brautigam","sequence":"first","affiliation":[{"name":"Department of Biophysics The University of Texas Southwestern Medical Center Dallas Texas 75390"},{"name":"Department of Microbiology The University of Texas Southwestern Medical Center Dallas Texas 75390"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjit K.","family":"Deka","sequence":"additional","affiliation":[{"name":"Department of Microbiology The University of Texas Southwestern Medical Center Dallas Texas 75390"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Z.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Microbiology The University of Texas Southwestern Medical Center Dallas Texas 75390"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana R.","family":"Tomchick","sequence":"additional","affiliation":[{"name":"Department of Biophysics The University of Texas Southwestern Medical Center Dallas Texas 75390"},{"name":"Department of Biochemistry The University of Texas Southwestern Medical Center Dallas Texas 75390"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael V.","family":"Norgard","sequence":"additional","affiliation":[{"name":"Department of Microbiology The University of Texas Southwestern Medical Center Dallas Texas 75390"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Chlamydia trachomatis, Neisseria gonorrhoeae","author":"World Health Organization","year":"2011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.05.048"},{"key":"e_1_2_7_4_1","article-title":"Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen","author":"Radolf JD","journal-title":"Nat Rev 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