{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:21:59Z","timestamp":1784830919076,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Protein Science"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Amyloid A (AA) amyloidosis occurs spontaneously in many mammals and birds, but the prevalence varies considerably among different species, and even among subgroups of the same species. The Blue fox and the Gray fox seem to be resistant to the development of AA amyloidosis, while Island foxes have a high prevalence of the disease. Herein, we report on the identification of AA amyloidosis in the Red fox (<jats:italic>Vulpes vulpes<\/jats:italic>). Edman degradation and tandem MS analysis of proteolyzed amyloid protein revealed that the amyloid partly was composed of full\u2010length SAA. Its amino acid sequence was determined and found to consist of 111 amino acid residues. Based on inter\u2010species sequence comparisons we found four residue exchanges (Ser31, Lys63, Leu71, Lys72) between the Red and Blue fox SAAs. Lys63 seems unique to the Red fox SAA. We found no obvious explanation to how these exchanges might correlate with the reported differences in SAA amyloidogenicity. Furthermore, in contrast to fibrils from many other mammalian species, the isolated amyloid fibrils from Red fox did not seed AA amyloidosis in a mouse model.<\/jats:p>","DOI":"10.1002\/pro.3264","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T08:47:44Z","timestamp":1502268464000},"page":"2312-2318","source":"Crossref","is-referenced-by-count":4,"title":["Systemic AA amyloidosis in the red fox (<i>Vulpes vulpes<\/i>)"],"prefix":"10.1002","volume":"26","author":[{"given":"Anna","family":"Rising","sequence":"first","affiliation":[{"name":"Department of Anatomy Physiology and Biochemistry, Swedish University of Agricultural Sciences Uppsala 750 07 Sweden"},{"name":"Department of Neurobiology Care Sciences and Society (NVS), Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet Huddinge 141 57 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Cederlund","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Biophysics (MBB) Karolinska Institutet Stockholm 171 77 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Palmberg","sequence":"additional","affiliation":[{"name":"Center of Proteomics Karolinska (PKKI), Karolinska Institutet Stockholm 171 77 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Uhlhorn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Wildlife Diseases National Veterinary Institute (SVA) Uppsala 751 89 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gaunitz","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Care Sciences and Society (NVS), Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet Huddinge 141 57 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Nordling","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Care Sciences and Society (NVS), Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet Huddinge 141 57 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"\u00c5gren","sequence":"additional","affiliation":[{"name":"Department of Pathology and Wildlife Diseases National Veterinary Institute (SVA) Uppsala 751 89 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Ihse","sequence":"additional","affiliation":[{"name":"Department of Immunology Genetics and Pathology, Uppsala University Uppsala 751 85 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla T.","family":"Westermark","sequence":"additional","affiliation":[{"name":"Department of Medical Cell Biology 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