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The process of formation of amyloid fibrils is known as amyloidogenesis and attracts much attention as a potential target in the prevention and treatment of neurodegenerative conditions linked to protein aggregation. Cerebral deposition of amyloid aggregates of Tau is observed not only in AD but also in numerous other tauopathies and prion diseases. Amyloidogenesis of intrinsically unstructured monomers of Tau can be triggered by mutations in the Tau gene, post\u2010translational modifications, or interactions with polyanionic molecules and aggregation\u2010prone proteins\/peptides. The self\u2010assembly of amyloid fibrils of Tau shares a number of characteristic features with amyloidogenesis of other proteins involved in neurodegenerative diseases. For example,\n                    <jats:italic>in vitro<\/jats:italic>\n                    experiments have demonstrated that the nucleation phase, which is the rate\u2010limiting stage of Tau amyloidogenesis, is shortened in the presence of fragmented preformed Tau fibrils acting as aggregation templates (\u201cseeds\u201d). Accordingly, Tau aggregates released by tauopathy\u2010affected neurons can spread the neurodegenerative process in the brain through a prion\u2010like mechanism, originally described for the pathogenic form of prion protein. Moreover, Tau has been shown to form amyloid strains\u2014structurally diverse self\u2010propagating aggregates of potentially various pathological effects, resembling in this respect prion strains. Here, we review the current literature on Tau aggregation and discuss mechanisms of propagation of Tau amyloid in the light of the prion\u2010like paradigm.\n                  <\/jats:p>","DOI":"10.1002\/pro.3275","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T23:32:40Z","timestamp":1503012760000},"page":"2126-2150","source":"Crossref","is-referenced-by-count":154,"title":["Amyloidogenesis of Tau protein"],"prefix":"10.1002","volume":"26","author":[{"given":"Bartosz","family":"Nizynski","sequence":"first","affiliation":[{"name":"College of Inter\u2010Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, 2C Banacha Str Warsaw 02\u2010097 Poland"},{"name":"Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, 1 Pasteur Str Warsaw 02\u2010093 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