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In this respect, spiders as a highly diversified group of almost exclusive insect predators appear to possess infinite potential for the discovery of novel insect\u2010selective toxins. In 2003, a group of toxins was isolated from the spider<jats:italic>Macrothele gigas<\/jats:italic>and the amino acid sequence was reported. We obtained, by molecular biology techniques in a heterologous system, one of these toxins. 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