{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:36:32Z","timestamp":1790253392222,"version":"4.1.0"},"reference-count":166,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17SDG33410350"],"award-info":[{"award-number":["17SDG33410350"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006732","name":"New York University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Protein Science"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Proteotoxicity plays a key role in many devastating human disorders, including Alzheimer's, Huntington's and Parkinson's diseases; type 2 diabetes; systemic amyloidosis; and cardiac dysfunction, to name a few. The cellular mechanisms of proteotoxicity in these disorders have been the focus of considerable research, but their role in prevalent and morbid disorders, such as diabetes, is less appreciated. There is a large body of literature on the impact of glucotoxicity and lipotoxicity on insulin\u2010producing pancreatic \u03b2\u2010cells, and there is increasing recognition that proteotoxicty plays a key role. Pancreatic islet amyloidosis by the hormone IAPP, the production of advanced glycation endproducts (AGE), and insulin misprocessing into cytotoxic aggregates are all sources of \u03b2\u2010cell proteotoxicity in diabetes. AGE, produced by the reaction of reducing sugars with proteins and lipids are ligands for the receptor for AGE (RAGE), as are the toxic pre\u2010fibrillar aggregates of IAPP produced during amyloid formation. The mechanisms of amyloid formation by IAPP <jats:italic>in vivo<\/jats:italic> or <jats:italic>in vitro<\/jats:italic> are not well understood, and the cellular mechanisms of IAPP\u2010induced \u03b2\u2010cell death are not fully defined. Here, we review recent findings that illuminate the factors and mechanisms involved in \u03b2\u2010cell proteotoxicity in diabetes. Together, these new insights have far\u2010reaching implications for the establishment of unifying mechanisms by which pathological amyloidoses imbue their injurious effects <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/pro.3425","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T12:07:11Z","timestamp":1523966831000},"page":"1166-1180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The receptor for advanced glycation endproducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and exploiting common ground for novel amyloidosis therapies"],"prefix":"10.1002","volume":"27","author":[{"given":"Andisheh","family":"Abedini","sequence":"first","affiliation":[{"name":"Diabetes Research Program, Division of Endocrinology, Department of Medicine New York University Medical Center, 550 First Avenue, Smilow 906 New York New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Derk","sequence":"additional","affiliation":[{"name":"Diabetes Research Program, Division of Endocrinology, Department of Medicine New York University Medical Center, 550 First Avenue, Smilow 906 New York New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Marie","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Diabetes Research Program, Division of Endocrinology, Department of Medicine New York University Medical Center, 550 First Avenue, Smilow 906 New York New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/416507a"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85210"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4878-07.2008"},{"key":"e_1_2_8_5_1","first-page":"672","article-title":"The role of RAGE in amyloid\u2010beta peptide\u2010mediated pathology in Alzheimer's disease","volume":"10","author":"Schmidt AM","year":"2009","journal-title":"Curr Opin Investig Drugs"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1717-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/76216"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1935"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1255-x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2338-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001015"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-17-0138"},{"key":"e_1_2_8_13_1","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2017"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.03.024"},{"key":"e_1_2_8_15_1","unstructured":"The Center for Disease Control. National Diabetes Statistics Report 2014.https:\/\/www.cdc.gov\/diabetes\/pdfs\/data\/2014-report-estimates-of-diabetes-and-its-burden-in-the-united-states.pdf"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-S002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1817"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051591"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/35008121"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06320.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050657"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1681\/ASN.V1261264","article-title":"Glucose\u2010modified proteins modulate essential functions and apoptosis of polymorphonuclear leukocytes","volume":"12","author":"Cohen G","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003910170018"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19990715)57:2<280::AID-JNR14>3.0.CO;2-U"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050108"},{"key":"e_1_2_8_26_1","first-page":"1176","article-title":"Aminoguanidine and the effects of modified LDL on cultured retinal capillary cells","volume":"41","author":"Lyons TJ","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(99)00094-7"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.12.1094"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202634200"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080768"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.12.021"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2174\/15672050113109990009"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303925200"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.11.4766"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00310-5"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2510208.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040833"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.02.018"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2682"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-017-0505-x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161208784139693"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143345"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt258"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.05.005"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(02)00070-0"},{"key":"e_1_2_8_46_1","first-page":"1013","article-title":"Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs","volume":"44","author":"Thornalley P","year":"1998","journal-title":"Cell Mol Biol"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(00)00087-2"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63945-4"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64354-4"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(01)00239-9"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200113932"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-19-07576.2001"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)01224-1"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-011-0030-x"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.169276"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2010.05.017"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.277731"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42137-0"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801465200"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200114002"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.4161\/pri.5.3.16328"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.05.020"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310124200"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-7-17"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00776.x"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2058-z"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.7.1155"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363861"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2007.07.003"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1342"},{"key":"e_1_2_8_71_1","first-page":"813","article-title":"RAGE ligands induce apoptotic cell death of pancreatic \u03b2\u2010cells via oxidative stress","volume":"26","author":"Lee B","year":"2010","journal-title":"Int J Mol Med"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12036"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.11.085"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.1.273"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2390"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018782"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1253-1"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00042.2009"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00285291"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0407"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)77825-9"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1566"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008423200"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.7.2117"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi7004834"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi4015488"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2798269"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0405"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(01)00078-3"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-17-0105"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi051432v"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi401164k"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.10.052"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzm076"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)01377-3"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi500592p"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.062486907"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi050840w"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2011.06.012"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzp036"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.07.077"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.145"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/6\/1\/015005"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi701427q"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.036509.108"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00703.2009"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2010.04.012"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00274.2009"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2010.03.006"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.01.017"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12977"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090532"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2008.10.009"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R800016200"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1671-6"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2143-3"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.9.2304"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1715-y"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1672"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2451-2"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbir.2000.0643"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308244200"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002854"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep04267"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0178"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77506"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.024190"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1329-4"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.4.1988"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2010.00065.x"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.111"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2639"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.3.491"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69625"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71981"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69866"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.050708.133622"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305517110"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.01.048"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b01016"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3304-y"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0863"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2011.00100.x"},{"key":"e_1_2_8_144_1","first-page":"2148","article-title":"Seven mutations in the human insulin gene linked to permanent neonatal\/infancy\u2010onset diabetes mellitus","volume":"118","author":"Colombo C","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-11-42"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1091"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16485-0"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.562355"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702697104"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051251"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1214"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.2.604"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3868-9"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1347-2"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.08.009"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.08.013"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2350-y"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1474"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa2628"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1056"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.12.020"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0132"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158166"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160503C"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.10.6360"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1067"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-016-9691-1"}],"container-title":["Protein Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpro.3425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pro.3425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T12:40:17Z","timestamp":1694781617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pro.3425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":166,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1002\/pro.3425"],"URL":"https:\/\/doi.org\/10.1002\/pro.3425","archive":["Portico"],"relation":{},"ISSN":["0961-8368","1469-896X"],"issn-type":[{"value":"0961-8368","type":"print"},{"value":"1469-896X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"2018-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}