{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:05:26Z","timestamp":1790625926298,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T00:00:00Z","timestamp":1571356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005278","name":"Universidad de Antioquia","doi-asserted-by":"publisher","award":["Sostenibilidad to J.G.M."],"award-info":[{"award-number":["Sostenibilidad to J.G.M."]}],"id":[{"id":"10.13039\/501100005278","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Protein Science"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The LUFS domain (LUG\/LUH, Flo8, single\u2010strand DNA\u2010binding protein [SSBP]) is a well\u2010conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., <jats:italic>Protein Sci<\/jats:italic>., 2019, 28:788\u2013793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, <jats:italic>Candida auris<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/pro.3727","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T15:24:26Z","timestamp":1568129066000},"page":"2024-2029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen <i>Candida auris<\/i>"],"prefix":"10.1002","volume":"28","author":[{"given":"Elizabeth","family":"Misas","sequence":"first","affiliation":[{"name":"Cellular &amp; Molecular Biology Unit Corporaci\u00f3n para Investigaciones Biol\u00f3gicas  Medell\u00edn Colombia"},{"name":"Institute of Biology, Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Escand\u00f3n","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda Instituto Nacional de Salud  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan G.","family":"McEwen","sequence":"additional","affiliation":[{"name":"Cellular &amp; Molecular Biology Unit Corporaci\u00f3n para Investigaciones Biol\u00f3gicas  Medell\u00edn Colombia"},{"name":"School of Medicine Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2881-3815","authenticated-orcid":false,"given":"Oliver K.","family":"Clay","sequence":"additional","affiliation":[{"name":"Cellular &amp; Molecular Biology Unit Corporaci\u00f3n para Investigaciones Biol\u00f3gicas  Medell\u00edn Colombia"},{"name":"Translational Microbiology and Emerging Diseases (MICROS), School of Medicine and Health Sciences Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.230352397"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3581"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-04-0871"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.12.3981-3993.2002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-003-0447-7"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601713103"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E05-06-0502"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinmicnews.2017.06.003"},{"key":"e_1_2_5_10_1","first-page":"15","article-title":"Molecular epidemiology of Candida auris in Colombia reveals a highly related, countrywide colonization with regional patterns in amphotericin B resistance","volume":"68","author":"Escandon P","year":"2019","journal-title":"Clin Infect Dis"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03081"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0187-x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.15698\/mic2016.07.512"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2332326100"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1863-z"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07779-6"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-32162-2"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-94-017-0443-4_7","volume-title":"Evolutionary theory and processes: Modern horizons","author":"Trifonov EN","year":"2004"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky530"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.007048"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00334-18"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/333210a0"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-019-09893-5"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty419"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1004"},{"key":"e_1_2_5_27_1","volume-title":"Gene control","author":"Latchman DS","year":"2015"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.12.2277"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02257464"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.1999.026"}],"container-title":["Protein Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpro.3727","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pro.3727","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pro.3727","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pro.3727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T19:11:20Z","timestamp":1694200280000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pro.3727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,18]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1002\/pro.3727"],"URL":"https:\/\/doi.org\/10.1002\/pro.3727","archive":["Portico"],"relation":{},"ISSN":["0961-8368","1469-896X"],"issn-type":[{"value":"0961-8368","type":"print"},{"value":"1469-896X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,18]]},"assertion":[{"value":"2019-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}