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The interaction between the SARS\u2010CoV\u20102 spike protein and the human receptor angiotensin\u2010converting enzyme 2, both of which contain several cysteine residues, is impacted by the disulfide\u2010thiol balance in the host cell. The host cell redox status is affected by oxidative stress due to the imbalance between the reactive oxygen\/nitrogen species and antioxidants. Recent studies have shown that Vitamin D supplementation could reduce oxidative stress. It has also been proposed that vitamin D at physiological concentration has preventive effects on many viral infections, including COVID\u201019. However, the molecular\u2010level picture of the interplay of vitamin D deficiency, oxidative stress, and the severity of COVID\u201019 has remained unclear. Herein, we present a thorough review focusing on the possible molecular mechanism by which vitamin D could alter host cell redox status and block viral entry, thereby preventing COVID\u201019 infection or reducing the severity of the disease.<\/jats:p>","DOI":"10.1002\/pro.4190","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T22:25:05Z","timestamp":1632522305000},"page":"2206-2220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Vitamin D and <scp>COVID<\/scp>\u201019: A review on the role of vitamin D in preventing and reducing the severity of <scp>COVID<\/scp>\u201019 infection"],"prefix":"10.1002","volume":"30","author":[{"given":"Mobeen","family":"Abdrabbo","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Wisconsin\u2010Eau Claire  Eau Claire Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cole M.","family":"Birch","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Wisconsin\u2010Eau Claire  Eau Claire Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Wisconsin\u2010Eau Claire  Eau Claire Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey A.","family":"Cicigoi","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Wisconsin\u2010Eau Claire  Eau Claire Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Coffey","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Wisconsin\u2010Eau Claire  Eau Claire Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor C.","family":"Dolan","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Wisconsin\u2010Eau Claire  Eau Claire Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Dvorak","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Wisconsin\u2010Eau Claire  Eau Claire Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ava C.","family":"Gehrke","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Wisconsin\u2010Eau Claire  Eau Claire Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey E. 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