{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:55:04Z","timestamp":1765806904678},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T00:00:00Z","timestamp":1230681600000},"content-version":"vor","delay-in-days":3986,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Protein Science"],"published-print":{"date-parts":[[1998,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Crotalus adamanteus<\/jats:italic> snake venom adamalysin II is the structural prototype of the adamalysin or ADAM family comprising proteolytic domains of snake venom metalloproteinases, multimodular mammalian reproductive tract proteins, and tumor necrosis factor \u03b1 convertase, TACE, involved in the release of the inflammatory cytokine, TNF\u03b1. The structure of adamalysin II in noncovalent complex with two small\u2010molecule right\u2010hand side peptidomimetic inhibitors (Pol 647 and Pol 656) has been solved using X\u2010ray diffraction data up to 2.6 and 2.8 \u00c5 resolution. The inhibitors bind to the \u2010side of the proteinase, inserting between two protein segments, establishing a mixed parallel\u2010antiparallel three\u2010stranded \u03b2\u2010sheet and coordinate the central zinc ion in a bidentate manner via their two C\u2010terminal oxygen atoms. The proteinase\u2010inhibitor complexes are described in detail and are compared with other known structures. An adamalysin\u2010based model of the active site of TACE reveals that these small molecules would probably fit into the active site cleft of this latter metalloproteinase, providing a starting model for the rational design of TACE inhibitors.<\/jats:p>","DOI":"10.1002\/pro.5560070207","type":"journal-article","created":{"date-parts":[[2010,7,12]],"date-time":"2010-07-12T06:29:51Z","timestamp":1278916191000},"page":"283-292","source":"Crossref","is-referenced-by-count":41,"title":["Structures of adamalysin II with peptidic inhibitors. 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