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By utilizing their outer surface molecules, spirochetes can effectively modulate their dissemination, interact with immune system regulators, and select specific destination niches within the host. The three\u2010dimensional structures of multiple spirochetal surface proteins have been elucidated, providing insight into their <jats:italic>modus operandi<\/jats:italic>. This review focuses on the structural characteristics of these sticky molecules and their functional implications, highlighting how these features contribute to the pathogenicity of spirochetes and their ability to persist in the host and vector environments. 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