{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:27:26Z","timestamp":1787761646470,"version":"build-2784847793"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5U54AI170855"],"award-info":[{"award-number":["5U54AI170855"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM120604"],"award-info":[{"award-number":["GM120604"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Protein Science"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Traditional approaches to teaching structural biology struggle to capture the dynamic, three\u2010dimensional nature of biomolecular structures. Viral capsids, which employ quasi\u2010symmetric arrangements, are especially difficult to conceptualize at the human scale. While physical models can illustrate geometry, they are costly, static, and disconnected from the digital domain. Recent advances in mixed reality (MR) offer an opportunity to overcome these limitations by combining immersion, interactivity, and collaboration. We present\n                    <jats:italic>Virus Lesson<\/jats:italic>\n                    , an MR application designed to teach viral quasi\u2010symmetry through shared immersive experiences. Developed in Unity and optimized for standalone MR headsets such as the Meta Quest 3\/3S, the platform integrates multiplayer networking to allow students and instructors to co\u2010localize in the same virtual classroom. Activities include interactive exploration of virus size and composition, dissection of capsids to reveal encapsidated RNA, construction of quasi\u2010symmetric shells using Caspar\u2010Klug triangulation theory, and antibody\u2013antigen recognition tasks. Educational design elements such as spatially separated \u201clearning stations,\u201d memory palace techniques, and scaffolded problem\u2010solving guide learners through increasingly complex concepts. Pilot demos with participants of all ages showed high engagement, improved comprehension of virus structure, quasi\u2010symmetry, and immunological interactions, and strong appreciation of collaborative learning in MR. The\n                    <jats:italic>Virus Lesson<\/jats:italic>\n                    demonstrates that MR can enhance understanding of challenging structural biology concepts while providing a scalable framework for interactive, human\u2010scale education in biomolecular sciences.\n                  <\/jats:p>","DOI":"10.1002\/pro.70570","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:16:08Z","timestamp":1776086168000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The virus lesson: Teaching viral structure and\n                    <scp>quasi\u2010symmetry<\/scp>\n                    in mixed reality"],"prefix":"10.1002","volume":"35","author":[{"given":"Adam","family":"Gardner","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Cannac","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology The Scripps Research Institute  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Tallon","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology The Scripps Research Institute  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology The Scripps Research Institute  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2197-191X","authenticated-orcid":false,"given":"Ludovic","family":"Autin","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology The Scripps Research Institute  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10055-025-01118-z"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1962.027.001.005"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-65187-8_2"},{"key":"e_1_2_12_5_1","unstructured":"ChemalyTE GoyalM DuanT PhadnisV KhattarS VlaskampB et al.Geometry aware passthrough mitigates cybersickness.2025. 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