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Recently, the human import receptor TOM70 has been identified as a substrate of the serine\/threonine kinase DYRK1A. DYRK1A activates the metabolite carrier import pathway, and its impairment triggers a transcriptional adaptive response that induces remodeling of the TOM complex. This compensatory mechanism activates additional import pathways to mitigate reduced DYRK1A signaling. Patients with dysfunctional DYRK1A signaling exhibit clinical manifestations that resemble classical features of mitochondriopathies. The emerging\n                    <jats:italic>DYRK1A\u2010TOM70<\/jats:italic>\n                    axis therefore represents a central signaling platform coordinating mitochondrial protein import pathways in health and disease.\n                  <\/jats:p>","DOI":"10.1002\/pro.70631","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T12:19:23Z","timestamp":1779711563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Orchestrating mitochondrial protein import: The emerging role of\n                    <scp>DYRK1A<\/scp>\n                    in health and disease"],"prefix":"10.1002","volume":"35","author":[{"given":"Sahana","family":"Shankar","sequence":"first","affiliation":[{"name":"Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine University of Freiburg  Freiburg 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