{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:35:10Z","timestamp":1790768110765,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000844","name":"European Space Agency","doi-asserted-by":"publisher","award":["4000132935\/21\/NL\/CRS"],"award-info":[{"award-number":["4000132935\/21\/NL\/CRS"]}],"id":[{"id":"10.13039\/501100000844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Precision Radiation Oncology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      The scientific community shows great interest in the study of DNA damage induction, DNA damage repair, and the biological effects on cells and cellular systems after exposure to ionizing radiation. Several\n                      <jats:italic>in silico<\/jats:italic>\n                      methods have been proposed so far to study these mechanisms using Monte Carlo simulations. This study outlines a Geant4\u2010DNA example application, named \u201cmolecularDNA\u201d, publicly released in the 11.1 version of Geant4 (December 2022).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>It was developed for novice Geant4 users and requires only a basic understanding of scripting languages to get started. The example includes two different DNA\u2010scale geometries of biological targets, namely \u201ccylinders\u201d and \u201chuman cell\u201d. This public version is based on a previous prototype and includes new features, such as: the adoption of a new approach for the modeling of the chemical stage, the use of the standard DNA damage format to describe radiation\u2010induced DNA damage, and upgraded computational tools to estimate DNA damage response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Simulation data in terms of single\u2010strand break and double\u2010strand break yields were produced using each of the available geometries. The results were compared with the literature, to validate the example, producing less than 5% difference in all cases. Conclusion: \u201cmolecularDNA\u201d is a prototype tool that can be applied in a wide variety of radiobiology studies, providing the scientific community with an open\u2010access base for DNA damage quantification calculations. New DNA and cell geometries for the \u201cmolecularDNA\u201d example will be included in future versions of Geant4\u2010DNA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pro6.1186","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T06:31:28Z","timestamp":1676269888000},"page":"4-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Simulation of DNA damage using Geant4\u2010DNA: an overview of the \u201cmolecularDNA\u201d example application"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-9304","authenticated-orcid":false,"given":"Konstantinos P.","family":"Chatzipapas","sequence":"first","affiliation":[{"name":"University of Bordeaux, CNRS, LP2I Bordeaux, UMR 5797  Gradignan France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Hoang","family":"Tran","sequence":"additional","affiliation":[{"name":"University of Bordeaux, CNRS, LP2I Bordeaux, UMR 5797  Gradignan France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos","family":"Dordevic","sequence":"additional","affiliation":[{"name":"Vinca Institute of Nuclear Sciences, National Institute of the Republic of Serbia University of Belgrade, Vinca  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Zivkovic","sequence":"additional","affiliation":[{"name":"Vinca Institute of Nuclear Sciences, National Institute of the Republic of Serbia University of Belgrade, Vinca  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Zein","sequence":"additional","affiliation":[{"name":"University of Bordeaux, CNRS, LP2I Bordeaux, UMR 5797  Gradignan France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook\u2010Geun","family":"Shin","sequence":"additional","affiliation":[{"name":"Physics Division, Department of Radiation Oncology Massachusetts General Hospital &amp; Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dousatsu","family":"Sakata","sequence":"additional","affiliation":[{"name":"Division of Health Science Osaka University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathanael","family":"Lampe","sequence":"additional","affiliation":[{"name":"Unaffiliated  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M. C.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy Swinburne University of Technology  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Ristic\u2010Fira","sequence":"additional","affiliation":[{"name":"Vinca Institute of Nuclear Sciences, National Institute of the Republic of Serbia University of Belgrade, Vinca  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Petrovic","sequence":"additional","affiliation":[{"name":"Vinca Institute of Nuclear Sciences, National Institute of the Republic of Serbia University of Belgrade, Vinca  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Kyriakou","sequence":"additional","affiliation":[{"name":"Medical Physics Laboratory Department of Medicine University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Emfietzoglou","sequence":"additional","affiliation":[{"name":"Medical Physics Laboratory Department of Medicine University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Guatelli","sequence":"additional","affiliation":[{"name":"Centre for Medical Radiation Physics University of Wollongong  Wollongong New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Incerti","sequence":"additional","affiliation":[{"name":"University of Bordeaux, CNRS, LP2I Bordeaux, UMR 5797  Gradignan France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14010035"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12040799"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13290"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073770"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/ab6b47"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rpd\/ncy237"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13405"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246204"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lssr.2022.08.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2011.01.003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/09553002.2012.699136"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-38342-7_2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13048"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2015.10.087"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3476457"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1142\/S1793962310000122"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14037"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14036"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR15226.1"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2016.12.010"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13370"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14817"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nima.2016.06.125"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2006.869826"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9002(03)01368-8"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2018.02.011"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2017.12.008"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2019.04.010"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.5107511"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201075982\u2010x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13236046"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2021.05.029"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13194940"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2022.11.012"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14612"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radphyschem.2017.03.021"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2021.711317"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.15669\/pnst.2.503"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2006.14225"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14490"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcp.2014.06.011"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553008914551141"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/095530097143798"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006159"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.2307\/3578350"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2021.1948140"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.2307\/3580030"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/095530000138556"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553000050111569"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR3574.1"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0273-1177(01)00007-2"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553000400017895"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553000500530888"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2019.1549753"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/16878507.2020.1825035"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR15209.1"},{"key":"e_1_2_8_58_1","doi-asserted-by":"crossref","unstructured":"BrunR RadermakersF.ROOT \u2010 An object oriented data analysis framework. Nuclear Instruments and Methods in Physics Research Section A: Accelarators Spectrometers Detectors and Associated Equipment.1997;389:81\u201086.https:\/\/doi.org\/10.1016\/S0168-9002(97)00048-X","DOI":"10.1016\/S0168-9002(97)00048-X"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2014.09.024"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2016.03.003"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00610-2"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2001)156[0365:TLKMOD]2.0.CO;2"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00568-X"},{"key":"e_1_2_8_64_1","unstructured":"SciPy. Available:https:\/\/scipy.org\/"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03001"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR1165.1"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.689112"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26040840"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/aa54c9"}],"container-title":["Precision Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pro6.1186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pro6.1186","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pro6.1186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T23:15:09Z","timestamp":1692659709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pro6.1186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,13]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/pro6.1186"],"URL":"https:\/\/doi.org\/10.1002\/pro6.1186","archive":["Portico"],"relation":{},"ISSN":["2398-7324","2398-7324"],"issn-type":[{"value":"2398-7324","type":"print"},{"value":"2398-7324","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,13]]},"assertion":[{"value":"2022-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}