{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:30:42Z","timestamp":1789655442450,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Precision Radiation Oncology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Lattice radiotherapy can potentially deliver high doses to the tumor core, while conventional doses to the periphery resulting in improved response rates in large tumors (&gt; 5 cm). We assessed the feasibility of planning lattice radiotherapy and dosimetrically compared it with conventional radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective dosimetric study evaluated 10 patients with large tumors (&gt; 5 cm) treated with palliative intent with a dose of 20Gy in five fractions. High\u2010dose lattice points were created at doses of 50Gy in non\u2010hepatic tumors and 35Gy in hepatic tumors. Lattice plans were compared with treatment plans regarding dose coverage and organ\u2010at\u2010risk dosimetry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treated sites included soft tissue metastases to the neck, lungs, abdomen, pelvis, and liver. The mean lesion volume was 1103 cc (352\u20133173 cc). The maximum tumor size was 16 cm. The target volume coverage was &gt; 95% in all but one case (88% to achieve organ constraints). Dosimetry and organ\u2010at\u2010risk doses were similar in both palliative treatment and simulated lattice plans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lattice radiotherapy is feasible in large tumors using volumetric\u2010modulated arc therapy and achieves good coverage while meeting organ constraints. However, a prospective clinical evaluation is required to confirm its efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pro6.1248","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T06:48:21Z","timestamp":1732862901000},"page":"209-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Feasibility planning study of lattice radiotherapy for palliation in bulky tumors"],"prefix":"10.1002","volume":"8","author":[{"given":"Jayashree","family":"NP","sequence":"first","affiliation":[{"name":"Department of Radiotherapy and Oncology Kasturba Medical College, Manipal Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreekripa","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology Manipal College of Health Professionals, Manipal Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshul","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology Kasturba Medical College, Manipal Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh","family":"Velu","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology Kasturba Medical College, Manipal Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology Kasturba Medical College, Manipal Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5306-1649","authenticated-orcid":false,"given":"Shirley","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology Kasturba Medical College, Manipal Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2011.03.015"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.11.026"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k821"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14163909"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2021.08.011"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1667\/RADE-20-00066.1"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13133290"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/jmp.jmp_141_21"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2018.01.003"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1667\/RADE-20-00038.1"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.4263"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meddos.2023.12.003"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-22-1119"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2021.11.023"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1667\/RADE-20-00047.1"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2020.100639"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2022.02.010"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.66.6.728"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR3819.1"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-019-1410-1"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.1478"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.809279"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.9"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2021.09.004"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-22-965"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2019.05.004"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.12.288"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2019.10.004"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.06.1954"},{"issue":"2","key":"e_1_2_12_32_1","first-page":"161","article-title":"Dosimetric performance evaluation of MLC\u2010based and cone\u2010based 3D spatially fractionated LATTICE radiotherapy","volume":"199","author":"Ertan F","year":"2023","journal-title":"Radiat Res"}],"container-title":["Precision Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pro6.1248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T13:26:14Z","timestamp":1735219574000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pro6.1248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,28]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/pro6.1248"],"URL":"https:\/\/doi.org\/10.1002\/pro6.1248","archive":["Portico"],"relation":{},"ISSN":["2398-7324","2398-7324"],"issn-type":[{"value":"2398-7324","type":"print"},{"value":"2398-7324","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,28]]},"assertion":[{"value":"2024-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}