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This report presents two pathologically confirmed PTCL cases. Although cerebrospinal fluid (CSF) flow cytometry did not detect tumor cells, CSF analysis revealed significantly elevated interleukin (IL)\u201010 levels and an increased IL\u201010\/IL\u20106 ratio, suggesting CNS involvement. Following effective chemotherapy, which crossed the blood\u2010brain barrier, IL\u201010 levels and the IL\u201010\/IL\u20106 ratio decreased significantly, with clinical improvement. These findings suggest that IL\u201010 is a valuable supplementary diagnostic marker for CNS involvement in PTCL. Whole\u2010brain radiation therapy, as a consolidative treatment, may be effective for residual or refractory lesions and improve prognosis. We review these patients\u2019 clinical and diagnostic features and discuss the role of radiotherapy in the treatment of CNS involvement in PTCL.<\/jats:p>","DOI":"10.1002\/pro6.70018","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T02:04:47Z","timestamp":1756519487000},"page":"223-227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Peripheral T\u2010cell lymphoma with central nervous system involvement and elevated interleukin\u201010 levels in the cerebrospinal fluid: A case report"],"prefix":"10.1002","volume":"9","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Lymphoma Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan 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