{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:49:27Z","timestamp":1774957767192,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374229"],"award-info":[{"award-number":["82374229"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272839"],"award-info":[{"award-number":["81272839"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Precision Radiation Oncology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiation therapy (RT) is a cornerstone of cancer treatment that not only directly kills tumor cells but also produces synergistic effects with immunotherapy by remodeling the tumor immune microenvironment (TIME). However, systematic bibliometric analyses of RT\u2010TIME interactions remain unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study analyzed all the literature related to RT and TIME from the Web of Science (WOS) Core Collection through 2024. It utilized R, VOSviewer, and CiteSpace to visually analyze authors, countries, institutions, keywords, co\u2010cited references, research hotspots, and frontiers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      China, the United States, and Germany emerged as the leading contributors, with 1,253, 581, and 162 publications, respectively. Frontiers in Immunology was the most active journal (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0186). Co\u2010occurrence analysis identified \u201cradiotherapy\u201d (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0898) and \u201cimmunotherapy\u201d (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0895) as core themes, with sustained focus on \u201cCD8(+) T cells\u201d (citation burst = 8.81) and emerging interest in \u201c(nature killer) NK cells.\u201d Temporal evolution revealed three research phases: initial exploration (2007\u20132015) of RT's immunomodulatory mechanisms of RT, clinical validation of RT combined with Programmed Cell Death Protein 1 (PD\u20101)\/ Cytotoxic T\u2010Lymphocyte\u2010Associated Protein 4 (CTLA\u20104) inhibitors (2015\u20132020), and recent diversification (2020\u20132024) toward technical optimization (e.g., stereotactic RT), tumor type expansion, and safety management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This comprehensive bibliometric analysis highlights future priorities, including exploring optimal synergistic strategies for combination therapies, investigating spatiotemporally resolved immune mechanisms, and developing predictive biomarkers. These areas are currently experiencing rapid growth and require further research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pro6.70041","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T19:04:56Z","timestamp":1770491096000},"page":"48-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping the research landscape of the correlation between radiotherapy and tumor immune microenvironment: A bibliometric analysis"],"prefix":"10.1002","volume":"10","author":[{"given":"Shangyi","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"},{"name":"School of Medicine Xi'an Jiaotong University  Xi an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"},{"name":"School of Medicine Xi'an Jiaotong University  Xi an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongze","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"},{"name":"School of Medicine Xi'an Jiaotong University  Xi an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinran","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"},{"name":"School of Medicine Xi'an Jiaotong University  Xi an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lintao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine Xi'an Jiaotong University  Xi an China"},{"name":"Department of orthopedics Xi'an Central Hospital  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6784-4600","authenticated-orcid":false,"given":"Xinyu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"},{"name":"School of Medicine Xi'an Jiaotong University  Xi an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shupei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"},{"name":"School of Medicine Xi'an Jiaotong University  Xi an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xixi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0306-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1451"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0914"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0014-x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro6.1225"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e27103"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/520429a"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-018-2649-4"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-3004(02)00034-1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joi.2017.08.007"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11192-009-0146-3"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307513100"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8733(78)90021-7"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024940629314"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67313"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.09.012"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.3.799"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-206870"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.164.5.1652"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.211"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062056"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro6.1225"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1622"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3380"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052494"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-016-0635-5"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198687"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.12.018"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-004762"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0362-2"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abo5558"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00414"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0265"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.123068"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2024.07.170"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abh4050"}],"container-title":["Precision Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pro6.70041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pro6.70041","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pro6.70041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:55:27Z","timestamp":1774954527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pro6.70041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,7]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/pro6.70041"],"URL":"https:\/\/doi.org\/10.1002\/pro6.70041","archive":["Portico"],"relation":{},"ISSN":["2398-7324","2398-7324"],"issn-type":[{"value":"2398-7324","type":"print"},{"value":"2398-7324","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,7]]},"assertion":[{"value":"2025-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}