{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:25:09Z","timestamp":1787610309143,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Precision Radiation Oncology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>The clinical feasibility, dosimetric reproducibility, and in vivo accuracy of a tomotherapy\u2010based total\u2010body irradiation (TBI) protocol in a large cohort of patients undergoing hematopoietic stem cell transplantation (HSCT) is evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients (128 patients with hematological malignancies undergoing TBI with helical tomotherapy) were simulated in dual orientations (head\u2010first and feet\u2010first supine) to accommodate extended anatomical lengths. Plans were generated as separate upper and lower components with structured gradient overlap zones and then composited for delivery. Quality assurance included an ArcCHECK 3D diode array for patient\u2010specific gamma analysis (3%\/3 mm criteria), point\u2010dose verification, and in vivo dosimetry. The gamma pass rates, regional dose deviations, and Pearson correlation coefficients were analyzed. Statistical evaluation was performed using the Shapiro\u2013Wilk test, Levene's test, and ANOVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All treatment plans met the institutional constraints for planning target volume (PTV) coverage and organs at risk sparing. The mean D95% of the PTV consistently exceeded 95% of the prescribed dose, ensuring robust target coverage. This reflects excellent conformity with the planned dose distribution. Region\u2010wise gamma pass rates exceeded 97% in all areas except junctions, where rates were slightly lower owing to dose gradients. The point\u2010dose agreement showed tight clustering within the \u00b13% range, with the pelvis exhibiting the most significant positive shift. The in vivo optically stimulated luminescence dosimeter dose remained within the clinically acceptable range of 0.8\u20131.2 Gy. A strong interregional correlation (\n                      <jats:italic>r<\/jats:italic>\n                      &gt; 0.90) was observed, confirming reproducibility. ANOVA identified statistically significant but clinically acceptable regional dose variations (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.030).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tomotherapy\u2010based TBI demonstrated high dosimetric precision, reproducibility, and workflow efficiency. This protocol offers a clinically reliable approach for modern TBI delivery in transplant conditioning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pro6.70049","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:37:56Z","timestamp":1768894676000},"page":"88-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Engineering dosimetric excellence in total body irradiation: Tomotherapy\u2010driven protocols for precision and reproducibility"],"prefix":"10.1002","volume":"10","author":[{"given":"Sandeep","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Division of Medical Physics Rajiv Gandhi Cancer Institute and Research Center  New Delhi India"},{"name":"Department of Physics GLA University  Mathura Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Dipesh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Medical Physics Rajiv Gandhi Cancer Institute and Research Center  New Delhi India"},{"name":"Department of Physics GLA University  Mathura Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supratik","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Medical Physics Rajiv Gandhi Cancer Institute and Research Center  New Delhi India"},{"name":"Department of Radiation Oncology Dr. B. Borooah Cancer Institute  Guwahati Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Medical Physics Rajiv Gandhi Cancer Institute and Research Center  New Delhi India"},{"name":"Department of Physics GLA University  Mathura Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Mahipal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Medical Physics Rajiv Gandhi Cancer Institute and Research Center  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manindra","family":"Bhushan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Medical Physics Rajiv Gandhi Cancer Institute and Research Center  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaskaran Singh","family":"Sethi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rajiv Gandhi Cancer Institute and Research Center  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Simson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rajiv Gandhi Cancer Institute and Research Center  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munish","family":"Gairola","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rajiv Gandhi Cancer Institute and Research Center  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2023.107416"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-018-2412-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.774853"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2025.104898"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radphyschem.2025.112541"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2016.03.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radphyschem.2025.112965"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v15i5.4724"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2019.01.30"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phro.2025.100741"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.15410"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tipsro.2025.100316"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.596958"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2025.110822"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.774348"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(99)80058-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0424"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.46989\/001c.120991"},{"issue":"2","key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jtct.2020.10.018","article-title":"Prognostic Impact of the Fractionation of Total Body Irradiation for Patients with Acute Myeloid Leukemia Undergoing Myeloablative Allogeneic Hematopoietic Cell Transplantation","volume":"27","author":"Ueda N","year":"2021","journal-title":"Transplant Cell Ther"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(83)90067-6"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2015.476"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.31164"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-04657-7"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8043(98)00024-4"},{"key":"e_1_2_10_26_1","unstructured":"SOMATOM go.Sim \u2010 Siemens Healthineers India. 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