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As a binary, target\u2010specific therapeutic modality for malignancies, BNCT critically depends on novel boron delivery carriers that exhibit high tumor affinity and prolonged intratumoral retention. Although several boron carriers have received Food and Drug Administration approval for clinical investigation, leading carriers such as L\u2010p\u2010boronophenylalanine (BPA) and sodium borocaptate (BSH) continue to require high infusion doses and exhibit limited tumor selectivity and affinity, short systemic half\u2010lives, and limited in vivo stability. These challenges have stimulated extensive global research into novel boron\u201010 carriers and innovative carrier platforms, including amino acids, sugars, porphyrin derivatives, nucleotides, and a variety of nanocarrier systems. This review provides a systematic classification of high\u2010abundance boron\u201010 carriers, critically examines radio\u2010boron research, and evaluates the potential integration of BNCT into clinical diagnostics and advanced cancer treatment protocols. By detailing the current status of novel boron\u201010 carriers, this review further aims to elucidate critical challenges and opportunities in BNCT drug development, ultimately providing a theoretical foundation for next\u2010generation BNCT interventions.\n                  <\/jats:p>","DOI":"10.1002\/pro6.70061","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:35:11Z","timestamp":1775640911000},"page":"205-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Boron\u201010 carriers and their applications in boron neutron capture therapy"],"prefix":"10.1002","volume":"10","author":[{"given":"Dachao","family":"Tang","sequence":"first","affiliation":[{"name":"School of Petrochemical Engineering Changzhou University  Changzhou China"},{"name":"Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors The Tenth Affiliated Hospital Southern Medical University (Dongguan People's Hospital) Southern Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8379-5202","authenticated-orcid":false,"given":"Mengqi","family":"Shi","sequence":"additional","affiliation":[{"name":"Departments of Diagnostic Radiology Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichen","family":"Mao","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors The Tenth Affiliated Hospital Southern Medical University (Dongguan People's Hospital) Southern Medical University  Dongguan China"},{"name":"Cancer Center Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs The Tenth Affiliated Hospital Southern Medical University (Dongguan People's Hospital) Southern Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiya","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy China Pharmaceutical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors The Tenth Affiliated Hospital Southern Medical University (Dongguan People's Hospital) Southern Medical University  Dongguan China"},{"name":"Cancer Center Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs The Tenth Affiliated Hospital Southern Medical University (Dongguan People's Hospital) Southern Medical University  Dongguan 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