{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:06:01Z","timestamp":1790348761254,"version":"4.1.0"},"reference-count":148,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Precision Radiation Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Proton therapy, an emerging radiation therapy technique, has gained significant attention owing to its unique physical properties and biological effects. This review aims to explore the impact of proton therapy on the tumor immune system and of its combination with other therapies. This review outlines the fundamental principles and oncological applications of proton therapy, followed by an analysis of its impact on the immune system\u2014encompassing draining lymph nodes, peripheral blood immune cells, tumor cell immune responses, and the tumor microenvironment. We further discuss current combinatorial strategies with immunotherapy and\/or chemotherapy, which point toward promising clinical directions.<\/jats:p>","DOI":"10.1002\/pro6.70089","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T05:19:33Z","timestamp":1787375973000},"page":"388-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of proton therapy on the tumor immune system and clinical implications: A review"],"prefix":"10.1002","volume":"10","author":[{"given":"Rundong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Oncology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Oncology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0744-2323","authenticated-orcid":false,"given":"Min","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Oncology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjia","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Pittsburgh Graduate School of Public Health, Pittsburgh  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8050-9576","authenticated-orcid":false,"given":"Zhen","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Oncology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8060-4917","authenticated-orcid":false,"given":"Guangyuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Oncology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12194\u2010009\u20100081\u20102"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880\u2010019\u20100407\u20103"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1667\/rr13538.1"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.09.040"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102005\u20106\u20103\u2010211"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2703"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.Can\u201011\u20104094"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-200109000-00002"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.06.021"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw168"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602754"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010021\u201000524\u2010x"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2022.6"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13390"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2018.08.014"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2023.101189"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186x.2017.1324207"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2018.03.28"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010023\u201011031\u2010w"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.55.1945"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/47.5.487"},{"issue":"2","key":"e_1_2_18_23_1","first-page":"121","article-title":"Pituitary irradiation with high\u2010energy proton beams: a preliminary report","volume":"18","author":"Lawrence JH","year":"1958","journal-title":"Cancer Res"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.70752"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.70121"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v105.43602"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.14740\/jmc4351"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2024.12.027"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20190226"},{"issue":"9","key":"e_1_2_18_30_1","first-page":"577","article-title":"The price of anticancer intervention. Secondary malignancies after radiotherapy","volume":"3","author":"Hoskin P","year":"2002","journal-title":"Lancet Oncol"},{"key":"e_1_2_18_31_1","doi-asserted-by":"publisher","DOI":"10.14338\/ijpt\u201020\u201000041.1"},{"key":"e_1_2_18_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2025.06.3859"},{"key":"e_1_2_18_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604\u2010024\u201001663\u20108"},{"key":"e_1_2_18_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2025.111307"},{"key":"e_1_2_18_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2025.102939"},{"key":"e_1_2_18_36_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v16.i3.102872"},{"key":"e_1_2_18_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176337"},{"key":"e_1_2_18_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrz032"},{"key":"e_1_2_18_39_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170934"},{"key":"e_1_2_18_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11040308"},{"key":"e_1_2_18_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194745"},{"key":"e_1_2_18_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110422"},{"key":"e_1_2_18_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2017.56"},{"key":"e_1_2_18_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2019.1558297"},{"key":"e_1_2_18_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.05.015"},{"key":"e_1_2_18_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2025.104745"},{"key":"e_1_2_18_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2025.04.008"},{"key":"e_1_2_18_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1088129"},{"key":"e_1_2_18_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2022.188704"},{"key":"e_1_2_18_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/17588359251387534"},{"key":"e_1_2_18_51_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201017\u20103427"},{"key":"e_1_2_18_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201034676\u2010w"},{"key":"e_1_2_18_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102020\u2010000867"},{"key":"e_1_2_18_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2025.110801"},{"key":"e_1_2_18_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2018.01.003"},{"key":"e_1_2_18_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1560"},{"key":"e_1_2_18_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2018.01.004"},{"key":"e_1_2_18_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364\u2010024\u201000628\u20103"},{"key":"e_1_2_18_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202201734"},{"key":"e_1_2_18_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2024.2324472"},{"key":"e_1_2_18_61_1","doi-asserted-by":"publisher","DOI":"10.2147\/jhc.S282062"},{"key":"e_1_2_18_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.04.025"},{"key":"e_1_2_18_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrac084"},{"key":"e_1_2_18_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13246193"},{"key":"e_1_2_18_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.05.064"},{"key":"e_1_2_18_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2023.110030"},{"key":"e_1_2_18_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpt.2024.100016"},{"key":"e_1_2_18_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066\u2010024\u201002263\u20101"},{"key":"e_1_2_18_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpt.2024.100110"},{"key":"e_1_2_18_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"e_1_2_18_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104\u2010016\u20102335\u20105"},{"key":"e_1_2_18_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7120512"},{"key":"e_1_2_18_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2024.2324471"},{"key":"e_1_2_18_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiae156"},{"key":"e_1_2_18_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.12.018"},{"key":"e_1_2_18_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxaf040"},{"key":"e_1_2_18_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2024.108421"},{"key":"e_1_2_18_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15153972"},{"key":"e_1_2_18_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.11.004"},{"key":"e_1_2_18_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759\u20107714.13122"},{"key":"e_1_2_18_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16112085"},{"key":"e_1_2_18_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201092942\u20101"},{"key":"e_1_2_18_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010025\u201006377\u20107"},{"key":"e_1_2_18_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2023.109741"},{"key":"e_1_2_18_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16051008"},{"key":"e_1_2_18_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12020332"},{"key":"e_1_2_18_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010025\u201000905\u20106"},{"key":"e_1_2_18_88_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.Cir\u201024\u20100902"},{"key":"e_1_2_18_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101151"},{"key":"e_1_2_18_90_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20232101"},{"key":"e_1_2_18_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2019.04.001"},{"key":"e_1_2_18_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14181"},{"key":"e_1_2_18_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.06.403"},{"key":"e_1_2_18_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw144"},{"key":"e_1_2_18_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2024.110577"},{"key":"e_1_2_18_96_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010110519\u2010071134"},{"key":"e_1_2_18_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010020\u201001820\u20107"},{"key":"e_1_2_18_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856\u2010023\u201000411\u20109"},{"key":"e_1_2_18_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.07.2360"},{"key":"e_1_2_18_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2017.02.001"},{"key":"e_1_2_18_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12986"},{"key":"e_1_2_18_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2012.09.001"},{"key":"e_1_2_18_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262\u2010016\u20101914\u20106"},{"key":"e_1_2_18_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.04.023"},{"key":"e_1_2_18_105_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20190224"},{"key":"e_1_2_18_106_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.2756"},{"key":"e_1_2_18_107_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095\u20103941.2024.0055"},{"key":"e_1_2_18_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14215285"},{"key":"e_1_2_18_109_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000002024"},{"key":"e_1_2_18_110_1","doi-asserted-by":"publisher","DOI":"10.36401\/jipo\u201023\u201020"},{"key":"e_1_2_18_111_1","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/20.229"},{"key":"e_1_2_18_112_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2023.502"},{"issue":"1","key":"e_1_2_18_113_1","first-page":"17","article-title":"Stereotactic body proton therapy for non\u2010small cell lung cancer: Clinical indications and recommendations","volume":"9","author":"McMillan MT","year":"2023","journal-title":"J Radiosurg SBRT"},{"key":"e_1_2_18_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2025.09.042"},{"key":"e_1_2_18_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010020\u201007484\u2010y"},{"key":"e_1_2_18_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.01.012"},{"key":"e_1_2_18_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.03.005"},{"key":"e_1_2_18_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014\u2010023\u201002372\u20108"},{"key":"e_1_2_18_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpt.2024.100009"},{"key":"e_1_2_18_120_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2403002121"},{"key":"e_1_2_18_121_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo\u201021\u2010593"},{"key":"e_1_2_18_122_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx287"},{"key":"e_1_2_18_123_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1685944"},{"key":"e_1_2_18_124_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.2.720"},{"key":"e_1_2_18_125_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201006\u20101183"},{"key":"e_1_2_18_126_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010022\u201001669\u20108"},{"key":"e_1_2_18_127_1","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000002549"},{"key":"e_1_2_18_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010021\u201000655\u20102"},{"key":"e_1_2_18_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010024\u201001625\u20107"},{"key":"e_1_2_18_130_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.918869"},{"key":"e_1_2_18_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.661606"},{"key":"e_1_2_18_132_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2017.03.07"},{"key":"e_1_2_18_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.813832"},{"key":"e_1_2_18_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010024\u201002079\u20108"},{"key":"e_1_2_18_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010020\u20100413\u2010z"},{"key":"e_1_2_18_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360\u20103016(79)90044\u20100"},{"key":"e_1_2_18_137_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.69.9678"},{"key":"e_1_2_18_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0950\u20103536(96)80024\u20102"},{"key":"e_1_2_18_139_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1990.8.7.1148"},{"key":"e_1_2_18_140_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/5"},{"key":"e_1_2_18_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010023\u201000856\u20102"},{"key":"e_1_2_18_142_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010024\u201003404\u20106"},{"key":"e_1_2_18_143_1","doi-asserted-by":"publisher","DOI":"10.1097\/js9.0000000000001546"},{"key":"e_1_2_18_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217133"},{"key":"e_1_2_18_145_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102024\u2010009617"},{"key":"e_1_2_18_146_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.929950"},{"key":"e_1_2_18_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjp2.246"},{"key":"e_1_2_18_148_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13164216"},{"key":"e_1_2_18_149_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac336"}],"container-title":["Precision Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pro6.70089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pro6.70089","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pro6.70089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:54:17Z","timestamp":1790348057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pro6.70089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":148,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/pro6.70089"],"URL":"https:\/\/doi.org\/10.1002\/pro6.70089","archive":["Portico"],"relation":{},"ISSN":["2398-7324","2398-7324"],"issn-type":[{"value":"2398-7324","type":"print"},{"value":"2398-7324","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]},"assertion":[{"value":"2025-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}