{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:56:41Z","timestamp":1790683001036,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502440"],"award-info":[{"award-number":["82502440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12475346"],"award-info":[{"award-number":["12475346"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Precision Radiation Oncology"],"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n \n Transarterial radioembolization (TARE) is an important locoregional therapy for hepatocellular carcinoma (HCC). However, clinically used yttrium\u201090 (\n 90<\/jats:sup>\n Y) microspheres are non\u2010biodegradable and provide limited imaging capability, while biodegradable polymeric microspheres prepared using conventional radiolabeling strategies often exhibit poor radionuclide stability.\n <\/jats:p>\n <\/jats:sec>\n \n Experimental design<\/jats:title>\n We designed a biodegradable radiometal\u2010chelating microsphere based on amidoxime\u2010functionalized polylactic acid microspheres (PLA\u2010g\u2010PAO\u2010Ms) engineered via electron beam\u2010induced graft polymerization.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The PLA\u2010g\u2010PAO\u2010Ms exhibited a high Lu\n 3+<\/jats:sup>\n loading capacity (33.83 mg g\n \u22121<\/jats:sup>\n ) and underwent controlled biodegradation in vitro after approximately 20 d. Cell Counting Kit\u20108 (CCK\u20108) assays confirmed favorable cytocompatibility, with both LO2 and HepG2 cell viabilities exceeding 90% after 72 h, showing no significant difference from the control group (\n p<\/jats:italic>\n > 0.05); by contrast, free Lu\n 3+<\/jats:sup>\n (50 mg\u00b7L\n \u22121<\/jats:sup>\n ) significantly reduced HepG2 viability to 51.4% (\n p<\/jats:italic>\n < 0.001). In a rat orthotopic liver tumor model, the intra\u2010arterial administration of\n 177<\/jats:sup>\n Lu\u2010labeled PLA\u2010g\u2010PAO\u2010Ms (\n 177<\/jats:sup>\n Lu\u2010PLA\u2010g\u2010PAO\u2010Ms) resulted in pronounced tumor suppression with sustained in vivo radionuclide retention for at least 14 d. Biodistribution analysis revealed selective tumor accumulation of\n \n 8.79 \u00b1 1.74 %ID g\n \u22121<\/jats:sup>\n <\/jats:bold>\n , significantly higher than that in normal liver (\n \n 1 \u00b1 0.54 %ID g\n \u22121<\/jats:sup>\n <\/jats:bold>\n ) and other organs (\n \n \u00a0\n P<\/jats:italic>\n < 0.001\n <\/jats:bold>\n ), whereas free\n 177<\/jats:sup>\n LuCl\n 3<\/jats:sub>\n showed minimal tumor uptake (\n \n 0.30 \u00b1 0.28 %ID g\n \u22121<\/jats:sup>\n <\/jats:bold>\n ) with predominant non\u2010target organ accumulation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n These findings suggest that PLA\u2010g\u2010PAO\u2010Ms provide a biodegradable microsphere system capable of stable radiometal incorporation and effective tumor suppression following intra\u2010arterial administration, offering a promising approach for interventional radionuclide therapy for HCC.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pro6.70094","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:01:32Z","timestamp":1790679692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["177<\/sup>\n Lu\u2010labeled amidoxime\u2010functionalized biodegradable microspheres for transarterial radioembolization of hepatocellular carcinoma"],"prefix":"10.1002","author":[{"given":"Xingliang","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Hepato\u2010Biliary\u2010Pancreatic\u2010Intestinal Disease Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College Nanchong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Applied Radiation Institute School of Environmental and Chemical Engineering Shanghai University Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Applied Radiation Institute School of Environmental and Chemical Engineering Shanghai University Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Hepato\u2010Biliary\u2010Pancreatic\u2010Intestinal Disease Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College Nanchong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Hepato\u2010Biliary\u2010Pancreatic\u2010Intestinal Disease Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College Nanchong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Cancer Center Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors The Tenth Affiliated Hospital Southern Medical University (Dongguan People's Hospital) Dongguan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdong","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Hepato\u2010Biliary\u2010Pancreatic\u2010Intestinal Disease Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College Nanchong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Shanghai Applied Radiation Institute School of Environmental and Chemical Engineering Shanghai University Shanghai P. R. 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