{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:55:47Z","timestamp":1791276947052,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["262300420180"],"award-info":[{"award-number":["262300420180"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Precision Radiation Oncology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In recent years, ultra\u2010high dose\u2010rate FLASH radiotherapy (FLASH\u2010RT) has emerged as a prominent research focus in radiation oncology. A series of preclinical data indicate that FLASH\u2010RT can achieve tumor\u2010killing efficacy that is not inferior to that of conventional radiotherapy (CONV\u2010RT) while significantly reducing radiation damage to normal tissues. This distinctive tissue\u2010sparing effect is known as the \u201cFLASH effect.\u201d Rapid progress has been made in the clinical translation and application of FLASH\u2010RT. Against this backdrop, the China Anti\u2010Cancer Association Radiation Oncology Committee and the Chinese Medical Doctor Association Radiation Oncology Physician Committee gathered a group of experts and compiled the \u201cExpert Consensus on Clinical Trial Design Guidelines for FLASH Radiotherapy\u201d based on the latest domestic and international research advancements. This document summarizes the latest advances in FLASH\u2010RT and offers practical guidance for its design and translational application in future clinical trials.<\/jats:p>","DOI":"10.1002\/pro6.70098","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:05:30Z","timestamp":1790154330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expert consensus on clinical trial design guidelines for FLASH radiotherapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-6546","authenticated-orcid":false,"given":"Hui","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The Affiliated Cancer Hospital of Zhengzhou University  Zhengzhou China"},{"name":"HNHC Key Laboratory of Henan Cancer Hospital  Zhengzhou 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Pathophysiology School of Basic Medical Sciences College of Medicine Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6934-0108","authenticated-orcid":false,"given":"Jing","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Informatics The Hong Kong Polytechnic University  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4270-2556","authenticated-orcid":false,"given":"Hong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Affiliated Cancer Hospital of Zhengzhou University  Zhengzhou China"},{"name":"HNHC Key Laboratory of Henan Cancer Hospital  Zhengzhou 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