{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:56:42Z","timestamp":1782982602303,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,9,25]],"date-time":"2001-09-25T00:00:00Z","timestamp":1001376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The treatment for chronic nonbacterial prostatitis (NBP) has not been established. Cernitin pollen\u2010extract (CN\u2010009) is reported to have therapeutic effects for NBP. The effects and mechanisms of CN\u2010009 were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten\u2010month\u2010old rats were used with administration of estradiol after castration, which were similar to human NBP histologically. Since CN\u2010009 consists of T\u201060 and GBX, these drugs were administered, respectively. The prostate was evaluated histopathologically including glandular damage (epithelial score), stromal ratio and immunohistochemical assays for epithelial function (PAP), stromal evaluation (Vimentin), cell proliferation (PCNA) and apoptosis (deoxyuridine triphosphate biotin nick end\u2010labeling (TUNEL)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Controls revealed severe acinar gland atrophy and stromal proliferation. CN\u2010009 showed diminished these damages. Epithelial score was better (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and PAP positive materials were more abundant in CN\u2010009 and GBX than in Controls. The stromal ratio was lower in CN\u2010009 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and T\u201060 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). There was no difference for PCNA positive cells in the epithelium and stroma, and TUNEL positive cells in epithelium. While, the number of TUNEL positive cells in the stroma of CN\u2010009 and T\u201060 increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that CN\u2010009 protects acinar epithelial cells mainly by GBX and also inhibits stromal proliferation in association with enhanced apoptosis mainly by T\u201060. Prostate 49:122\u2013131, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.1126","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:23:24Z","timestamp":1030310604000},"page":"122-131","source":"Crossref","is-referenced-by-count":45,"title":["Effect of cernitin pollen\u2010extract on experimental nonbacterial prostatitis in rats"],"prefix":"10.1002","volume":"49","author":[{"given":"Toshiyuki","family":"Kamijo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadaichi","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,9,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/147.5.807"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.4.604"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(99)00015-1"},{"key":"e_1_2_1_5_2","first-page":"144","article-title":"Prostatitis; diagnosis and treatment in primary care","volume":"22","author":"Donovan DA","year":"1997","journal-title":"Nurse Practitioner"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70377-9"},{"key":"e_1_2_1_7_2","first-page":"561","article-title":"A long term therapeutic experience with Cernilton in chronic prostatitis","volume":"34","author":"Jodai A","year":"1988","journal-title":"Acta Urol Jpn (Jpn.)"},{"key":"e_1_2_1_8_2","first-page":"1","article-title":"Antiprostatic hypertrophic action of Cernitin pollen\u2010extract (Cernilton)","volume":"31","author":"Ito R","year":"1986","journal-title":"Pharmacometrics (Jpn.)"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-2299(96)80051-3"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.97.5_267"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.91.385"},{"key":"e_1_2_1_12_2","first-page":"55","article-title":"Anti\u2010inflammatory effects of Cernitin pollen\u2010extract (Cernilton)","volume":"28","author":"Ito R","year":"1984","journal-title":"Pharmacometrics (Jpn.)"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/00173136009429444"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)41924-0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990120310"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0022-5347(17)63302-0","article-title":"Needle biopsy study of chronic prostatitis","volume":"96","author":"Schmidt JD","year":"1966","journal-title":"J Urol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68090-1"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990100307"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65548-4"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990050305"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365597909179995"},{"key":"e_1_2_1_22_2","first-page":"162","article-title":"Hemmung der Arachidonsaure\u2010Kaskade durch einen Exrakt aus Roggenpollen","volume":"41","author":"Loschen G","year":"1991","journal-title":"Arzneim\u2010Forsch Drug. 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