{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:39:50Z","timestamp":1762864790119,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,6,25]],"date-time":"2004-06-25T00:00:00Z","timestamp":1088121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cancer Research"},{"name":"The Ministry of Health, Labor, and Welfare of Japan"},{"DOI":"10.13039\/501100001700","name":"The Ministry of Education, Science, Sports, and Culture of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2005,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Parathyroid hormone\u2010related protein (PTHrP) is produced by cancer cells and has been suggested to be responsible for malignancy\u2010associated hypercalcemia and osteolysis after bone metatsases. Therefore, PTHrP is a promising target in the treatment of metastatic prostate cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Seven PTHrP\u2010derived peptides were prepared based on the HLA\u2010A2 binding motif. These peptide candidates were screened by their ability to induce peptide\u2010specific cytotoxic T lymphocytes (CTLs), and their ability to be recognized by immunoglobulin G (IgG).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Both the PTHrP<jats:sub>59\u201367<\/jats:sub> and PTHrP<jats:sub>42\u201351<\/jats:sub> peptides were found to efficiently induce peptide\u2010specific CTLs from peripheral blood mononuclear cells of HLA\u2010A2<jats:sup>+<\/jats:sup> prostate cancer patients with several HLA\u2010A2 subtypes. These CTLs showed HLA\u2010A2\u2010restricted cytotoxicity toward prostate cancer cells. IgG reactive to the PTHrP<jats:sub>42\u201351<\/jats:sub> peptide was frequently detected in prostate cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>These results indicate that these two new PTHrP peptides will be useful in the peptide\u2010based immunotherapy of HLA\u2010A2<jats:sup>+<\/jats:sup> prostate cancer patients, especially those with bone metastases. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.20133","type":"journal-article","created":{"date-parts":[[2004,6,25]],"date-time":"2004-06-25T18:05:24Z","timestamp":1088186724000},"page":"233-242","source":"Crossref","is-referenced-by-count":13,"title":["New epitope peptides derived from parathyroid hormone\u2010related protein which have the capacity to induce prostate cancer\u2010reactive cytotoxic T lymphocytes in HLA\u2010A2<sup>+<\/sup> prostate cancer patients"],"prefix":"10.1002","volume":"62","author":[{"given":"Akihisa","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Matsueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Shomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukari","family":"Takao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadao","family":"Kamidono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyogo","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,25]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_1_2_2","DOI":"10.3322\/canjclin.50.1.7"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_2","DOI":"10.1002\/pros.10130"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_2","DOI":"10.1002\/(SICI)1097-0045(199612)29:6<371::AID-PROS5>3.0.CO;2-B"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_2","DOI":"10.1002\/(SICI)1097-0045(19980615)36:1<39::AID-PROS6>3.0.CO;2-6"},{"doi-asserted-by":"publisher","key":"e_1_2_1_6_2","DOI":"10.1002\/(SICI)1097-0045(19990101)38:1<73::AID-PROS9>3.0.CO;2-V"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_2","DOI":"10.1200\/JCO.2000.18.23.3894"},{"doi-asserted-by":"publisher","key":"e_1_2_1_8_2","DOI":"10.1152\/physrev.1996.76.1.127"},{"doi-asserted-by":"publisher","key":"e_1_2_1_9_2","DOI":"10.4049\/jimmunol.169.9.4840"},{"doi-asserted-by":"publisher","key":"e_1_2_1_10_2","DOI":"10.1002\/1097-0142(20000615)88:12 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