{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:44:34Z","timestamp":1780663474500,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T00:00:00Z","timestamp":1090540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"US NIH","award":["NIA RO1 AG14960"],"award-info":[{"award-number":["NIA RO1 AG14960"]}]},{"DOI":"10.13039\/100010269","name":"The Wellcome Trust","doi-asserted-by":"crossref","award":["GR62869FR"],"award-info":[{"award-number":["GR62869FR"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Association of Urology (scholarship to I.L.)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2005,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prostate contains three glandular zones (central, peripheral, transition) with widely differing susceptibilities to cancer and benign prostatic hyperplasia (BPH). Most of the prostate is derived from urogenital sinus, but the central zone may be derived from Wolffian duct, in common with the seminal vesicles (SV). The peripheral zone is the most frequent site of cancer and the transition zone is the almost exclusive site of BPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We compared the histology and immunohistochemistry of the SV with those of the prostate zones in order to identify differences associated with susceptibility to disease or different embryological origins. Sections from the prostates of nine organ donors (aged 15\u201336) were stained for tissue\u2010specific markers, antigens previously shown to stain differentially between the zones and markers of cell proliferation and cell death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neuroendocrine cells were absent from the SV and significantly fewer neuroendocrine cells were seen in the central zone compared to the peripheral zone. Most of the SV epithelium stained for lactoferrin, compared to approximately one\u2010third of central zone and only 2% of peripheral zone epithelial cells. The proliferative index of the central zone was approximately 50% lower and the incidence of apoptotic cells approximately half that of the peripheral and transition zones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The central zone has features in common with both the SV and the other zones of the prostate. The higher incidence of proliferative diseases in the transition and peripheral zones may be associated with the higher rate of cell turnover observed in these zones. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.20149","type":"journal-article","created":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T21:00:38Z","timestamp":1090616438000},"page":"260-266","source":"Crossref","is-referenced-by-count":34,"title":["Comparison of the zones of the human prostate with the seminal vesicle: Morphology, immunohistochemistry, and cell kinetics"],"prefix":"10.1002","volume":"62","author":[{"given":"Istv\u00e1n","family":"Laczk\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Feneley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Masters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,7,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64260-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990020105"},{"issue":"3","key":"e_1_2_1_4_2","first-page":"11","article-title":"Normal and pathologic anatomy of prostate","volume":"17","author":"McNeal JE","year":"1981","journal-title":"Urology"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000471714"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000130303"},{"key":"e_1_2_1_7_2","volume-title":"Patologia urogenital: Biologia y Pathologia de la prostata","author":"Gil Vernet S","year":"1953"},{"key":"e_1_2_1_8_2","first-page":"92","article-title":"Benign nodular hyperplasia of the prostate: A review","volume":"14","author":"Franks LM","year":"1954","journal-title":"Ann R Coll Surg"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007012514118"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0045(19991001)41:2<99::AID-PROS4>3.0.CO;2-C"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1998.00752.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37954-5"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35083-8"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.1185"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61676-8"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/89.1.41"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)45242-6"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990120107"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990200109"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/00129039-200209000-00016","article-title":"Stereologic estimation of the number of neuroendocrine cells in normal human prostate detected by immunohistochemistry","volume":"10","author":"Santamaria L","year":"2002","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021015"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198808000-00003"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.148.1.51"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-198712000-00006"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199205000-00018"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198611000-00017"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0022-5347(17)40075-9","article-title":"Ultrasound anatomy of the prostate: The normal gland and anatomical variations","volume":"143","author":"Villers A","year":"1990","journal-title":"J Urol"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1485"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4500602"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(01)00021-5"},{"key":"e_1_2_1_31_2","first-page":"267","article-title":"Zonal origin of prostatic adenocarcinoma: Are there biologic differences between transition zone and peripheral zone adenocarcinomas of the prostate gland?","volume":"19","author":"Grignon DJ","year":"1994","journal-title":"J Cell Biochem Suppl"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910215)67:4 <1132::AID-CNCR2820671506>3.0.CO;2-K"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/49.3.347"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198812000-00001"},{"key":"e_1_2_1_35_2","first-page":"591","article-title":"Morphologic and neuroendocrine features of adenocarcinoma arising in the transition zone and in the peripheral zone of the prostate","volume":"8","author":"Van de Voorde WM","year":"1995","journal-title":"Mod Pathol"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.108.5.1959"},{"issue":"3","key":"e_1_2_1_37_2","first-page":"11","article-title":"Normal and pathologic anatomy of prostate","volume":"17","author":"McNeal JE","year":"1981","journal-title":"Urology"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(86)80042-5"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(02)00269-5"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990170104"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1998.00812.x"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.20149","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.20149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T21:34:01Z","timestamp":1700170441000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.20149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,23]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,2,15]]}},"alternative-id":["10.1002\/pros.20149"],"URL":"https:\/\/doi.org\/10.1002\/pros.20149","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,23]]}}}