{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:05:22Z","timestamp":1790885122094,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,7,13]],"date-time":"2005-07-13T00:00:00Z","timestamp":1121212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>To prospectively evaluate the feasibility, safety, morbidity, and preliminary efficacy of radiofrequency interstitial tumor ablation (RITA) for the focal treatment of patients with local prostate cancer recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Eleven patients with biopsy\u2010proven, hormone\u2010na\u00efve, clinically localized prostate cancer were enrolled in a prospective phase I\/II trial. Eight patients had failed prior radiation therapy and three were not candidates for curative primary therapy (median Gleason score 7 and 6, respectively). Median follow\u2010up was 20 months. All patients were treated with RITA in an office setting, under intravenous sedation and were discharged after the procedure. Radiofrequency energy was applied via needles placed transperineally under transrectal ultrasound guidance.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The placement of 1\/4 lesions was aborted in two patients due to increasing rectal temperature. Complications included transient macrohematuria (19%), bladder spasms (9%), and dysuria (9%). Serum PSA levels decreased after RITA &gt;50% in 90% of patients, &gt;\u200970% in 72% of patients, and &gt;\u200980% in 46% of patients. The mean PSA doubling time after RITA was slower than that before RITA (37\u2009\u00b1\u200922 months vs. 14\u2009\u00b1\u200913 months, <jats:italic>P<\/jats:italic>\u2009=\u20090.008). At 12 months after RITA, 50% of patients with sufficient follow\u2010up had no residual cancer on repeat systematic 12\u2010core biopsy cores and 67% were cancer\u2010free in biopsy cores sampled from the RITA\u2010treated areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>RITA treatment is a minimal invasive, rapid, user\u2010friendly, office\u2010based procedure that is well tolerated. Focal ablation with RITA results in effective local disease control in patients with non\u2010metastatic prostate cancer recurrence. Larger, prospective, multicenter clinical studies are needed to confirm these findings. Prostate. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.20242","type":"journal-article","created":{"date-parts":[[2005,9,13]],"date-time":"2005-09-13T20:51:57Z","timestamp":1126644717000},"page":"260-267","source":"Crossref","is-referenced-by-count":65,"title":["Pilot study of radiofrequency interstitial tumor ablation (RITA) for the treatment of radio\u2010recurrent prostate cancer"],"prefix":"10.1002","volume":"65","author":[{"given":"Shahrokh F.","family":"Shariat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigorios","family":"Raptidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muramoto","family":"Masatoschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Bergamaschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Slawin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.53.1.5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.17.1598"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199501000-00037"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(03)70010-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)04574-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65084-5"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00492-0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(03)70009-5"},{"key":"e_1_2_1_10_2","first-page":"165","article-title":"Radiofrequency ablation of hepatocellular carcinoma","volume":"57","author":"Curley SA","year":"2002","journal-title":"Minerva Chir"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/tvir.2002.36419"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.1997.11.251"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66145-9"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1998.00504.x"},{"key":"e_1_2_1_15_2","first-page":"50","article-title":"Transperineal radiofrequency interstitial tumor ablation of the prostate: Correlation of magnetic resonance imaging with histopathologic examination.PG\u2010986\u201092; Discussion 992\u2013993","author":"Djavan B","year":"1997","journal-title":"Urology"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930315)71:6<2031::AID-CNCR2820710618>3.0.CO;2-Q"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66347-1"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0045(20010301)46:4<281::AID-PROS1034>3.0.CO;2-A"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-003-0472-4"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000100220.46419.8b"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.17.1591"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.4.1030"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00717-3"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000094800.63501.15"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.20242","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.20242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T16:22:49Z","timestamp":1700151769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.20242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,13]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1002\/pros.20242"],"URL":"https:\/\/doi.org\/10.1002\/pros.20242","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,13]]}}}