{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:39:42Z","timestamp":1759333182666},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T00:00:00Z","timestamp":1118275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>Surfactant protein D (SP\u2010D) is a member of the collectin family of proteins, which are involved in host defense mechanisms in the lung. In the present study, we found that SP\u2010D is produced in the human prostate where it may play a role in innate immunity.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS AND RESULTS<\/jats:title><jats:p>Using reverse\u2010transcriptase PCR and Western blot analysis, we demonstrate that SP\u2010D mRNA and protein are present in human prostate tissue. In situ hybridization and immunohistochemistry revealed that SP\u2010D mRNA and protein are localized in epithelial cells of prostate glands. Prostate glands that are surrounded by inflammatory cells produce increased amounts of SP\u2010D protein. We also show that SP\u2010D inhibits the infection of LNCaP and P69SV40T prostate epithelial cells by <jats:italic>Chlamydia trachomatis<\/jats:italic> in an in vitro infection assay. Furthermore, using truncated human SP\u2010D mutants, we demonstrate that SP\u2010D binds to <jats:italic>Chlamydia trachomatis<\/jats:italic> via its carboxy\u2010terminal lectin domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our in vitro studies suggest that SP\u2010D protects the prostate from infection by pathogens. SP\u2010D protein levels are increased at sites of inflammation in the prostate, suggesting SP\u2010D may also contribute more generally to inflammatory regulation in the prostate. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.20292","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T16:46:43Z","timestamp":1118335603000},"page":"241-251","source":"Crossref","is-referenced-by-count":29,"title":["A role for surfactant protein D in innate immunity of the human prostate"],"prefix":"10.1002","volume":"65","author":[{"given":"Rebecca E.","family":"Oberley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelli L.","family":"Goss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Dahmoush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin 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