{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T03:25:39Z","timestamp":1700537139314},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,2,15]],"date-time":"2006-02-15T00:00:00Z","timestamp":1139961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>IGF\u2010I is an important growth and differentiative factor for osteoblasts and may have a role in defining prostate cancer risk and skeletal metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Conditioned media (CM) from human prostate cancer (PC), C4\u20102 and C4\u20102B, which produce osteoblastic lesions, and PC\u20103, which causes osteolysis, was added to MC3T3\u2010E1 bone cultures. SCID mice were injected intratibially with these engineered cells. Tumor bearing tibiae were analyzed by microCT and pQCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>CM from PC cells increased osteoblast proliferation and differentiation and was unaltered by the type of PC cell, IGF\u2010I antibodies, or exogenous IGF\u2010I and IGFBP2. Study of intratibial PC tumors in SCID mice showed that C4\u20102 cells grew slowly preserving bone structure, while PC\u20103 tumors caused rapid osteolysis. Overexpression of IGF\u2010I did not change either tumor progression or skeletal response.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>IGF\u2010I is neither necessary nor sufficient for the osteoblastic response to PC metastases. Prostate \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.20379","type":"journal-article","created":{"date-parts":[[2006,2,15]],"date-time":"2006-02-15T21:46:23Z","timestamp":1140039983000},"page":"789-800","source":"Crossref","is-referenced-by-count":13,"title":["IGF\u2010I secretion by prostate carcinoma cells does not alter tumor\u2010bone cell interactions in vitro or in 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