{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:31:04Z","timestamp":1792711864108,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,30]],"date-time":"2006-10-30T00:00:00Z","timestamp":1162166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic inflammation is postulated to contribute to prostate carcinogenesis. We developed a mouse model of chronic prostatitis to test whether infection\u2010induced chronic inflammation would incite reactive changes in prostatic epithelium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prostate tissues harvested from either phosphate\u2010buffered saline (PBS) or <jats:italic>E. coli<\/jats:italic>\u2010infected mice were evaluated for histological changes and immunostained for markers of oxidative stress and epithelial cell proliferation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As compared to PBS\u2010treated controls, mice infected with <jats:italic>E. coli<\/jats:italic> bacteria for 5 days showed foci of uniformly acute inflammation in the glandular lumen and a persitent inflammation at 12 weeks post\u2010inoculation in the stroma. Prostatic glands showing varying degrees of atypical hyperplasia and dysplasia had stronger staining for oxidative DNA damage and increased epithelial cell proliferation than normal prostatic glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data demonstrate that chronic inflammation induces reactive hyperplasia associated with oxidative stress injury and support the proposed linkage among inflammation, oxidative DNA damage, and prostate carcinogenesis. Prostate 67:14\u201321, 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.20445","type":"journal-article","created":{"date-parts":[[2006,10,30]],"date-time":"2006-10-30T19:57:26Z","timestamp":1162238246000},"page":"14-21","source":"Crossref","is-referenced-by-count":93,"title":["Chronic bacterial infection and inflammation incite reactive hyperplasia in a mouse model of chronic prostatitis"],"prefix":"10.1002","volume":"67","author":[{"given":"Johny E.","family":"Elkahwaji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixiong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter 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