{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:47:23Z","timestamp":1789948043413,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T00:00:00Z","timestamp":1232668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Our previous findings have shown that systemic administration of interleukin (IL)\u20101\u03b2 induces up\u2010regulation of nuclear factor\u2010kappa B (NF\u2010\u03baB) in mouse prostate tissue that may be responsible for leukocyte extravasation into prostate stroma. It has been hypothesized that NF\u2010\u03baB plays a role in the development of prostatitis, and that NF\u2010\u03baB activation might provide chemoattractive signals for leukocyte extravasation in the prostate.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>IL\u20101\u03b2 was administrated intravenously, alone or with dexamethasone (Dex), to separate groups of C57BL\/6J mice. Expression of NF\u2010\u03baB, chemoattractant receptors, and IL\u201017F in the prostates of the two groups of mice at various time periods following treatment was evaluated and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>IL\u20101\u03b2 administration up\u2010regulated NF\u2010\u03baB\/p65 activity in the mouse prostate. IL\u20101\u03b2 administration promoted extravasation and accumulation of CD45+ mononuclear cells but not neutrophils in the mouse prostate stroma. IL\u20101\u03b2 administration provided earlier (4 hr) CXCR1\/IL\u20108RA receptor expression in mouse prostate as a first signal, inducing capillary homing, adhesion, and initial extravasation of mononuclear cells into the prostate tissue. IL\u20101\u03b2 administration also induced relatively late (24 hr) up\u2010regulation of VCAM1 in the endothelial cells of microvessels and of IL\u201017F in prostate epithelium and in stromal infiltrating leukocytes. Concomitant administration of Dex, a known NF\u2010\u03baB inhibitor, resulted in significantly down\u2010regulated IL\u20101\u03b2\u2010induced NF\u2010\u03baB\/p65 activity, as well as reduced expression of chemokine receptors and IL\u201017F in mouse prostate tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Systemic IL\u20101\u03b2 administration induces NF\u2010\u03baB\u2010responsive genes to promote aberrant NF\u2010\u03baB\/p65 activity, which may be critical in the development of prostatitis through its role in the production of chemoattractant signals that promote extravasation and stromal accumulation of mononuclear cells (mainly by CXCR1\/IL\u20108RA), and initiation of a new wave of pro\u2010inflammatory signals favorable to chronic inflammation (mainly by IL\u201017F). Prostate 69:633\u2013643, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.20916","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T14:22:12Z","timestamp":1232720532000},"page":"633-643","source":"Crossref","is-referenced-by-count":27,"title":["Il\u20101\u03b2\u2010induced post\u2010transition effect of NF\u2010kappaB provides time\u2010dependent wave of signals for initial phase of intrapostatic inflammation"],"prefix":"10.1002","volume":"69","author":[{"given":"Eugene V.","family":"Vykhovanets","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T.","family":"MacLennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena 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