{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:01:25Z","timestamp":1761217285064},"reference-count":26,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2009,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Anti\u2010inflammatory medications have been used for the treatment of chronic prostatitis. The phytotherapeutic agent Eviprostat\u00ae, a popular treatment for benign prostatic hyperplasia in Japan and Germany, has antioxidant and anti\u2010inflammatory activity. We investigated the effects of the phytotherapeutic agent Eviprostat\u00ae on prostate inflammation induced in castrated rats by the injection of 17\u03b2\u2010estradiol.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Ten\u2010month\u2010old male Wistar rats were divided into five groups. Nonbacterial prostatitis was experimentally induced in groups 2\u20135 by castration followed by daily subcutaneous injection of 17\u03b2\u2010estradiol for 30 days. The rats were orally administered 0.1% Tween\u201080 (group 2), low\u2010dose Eviprostat (group 3), high\u2010dose Eviprostat (group 4), or cernitin pollen extract (group 5) for the last 2 weeks of 17\u03b2\u2010estradiol administration. Sham\u2010operated rats (group 1) were orally administered 0.1% Tween\u201080. On the 31st day after surgery, the weight of the prostate and the levels of prostatic proinflammatory cytokines as well as the oxidative\u2010stress marker malondialdehyde were determined and histological alterations noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Experimentally induced nonbacterial prostatitis led to a significant decrease in prostate weight and increases in malondialdehyde and proinflammatory cytokine levels. Eviprostat significantly suppressed the increases in malondialdehyde and cytokine levels without affecting prostate weight. Histologically, nonbacterial prostatitis was evident in the lateral lobe of the prostate, and Eviprostat treatment significantly suppressed the severity of the lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Eviprostat, which has effective antioxidant and anti\u2010inflammatory activities in the prostate, may be useful for the clinical treatment of chronic prostatitis. These activities of Eviprostat may also contribute to the amelioration of prostate inflammation in BPH patients. Prostate 69: 1404\u20131410, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.20985","type":"journal-article","created":{"date-parts":[[2009,6,2]],"date-time":"2009-06-02T04:47:08Z","timestamp":1243918028000},"page":"1404-1410","source":"Crossref","is-referenced-by-count":22,"title":["Effect of the phytotherapeutic agent Eviprostat\u00ae on 17\u03b2\u2010estradiol\u2010induced nonbacterial inflammation in the rat prostate"],"prefix":"10.1002","volume":"69","author":[{"given":"Michiko","family":"Oka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Kyotani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsushi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63564-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.3.236"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4500930"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67497-6"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.07.016"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)00613-5"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.09.023"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2007.04.006"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.02.104"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)41924-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2001.02193.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990120310"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.1126"},{"key":"e_1_2_1_15_2","first-page":"96","article-title":"Phenotypic characterization of infiltrating leukocytes in benign prostatic hyperplasia","volume":"66","author":"Theyer G","year":"1992","journal-title":"Lab Invest"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1989.tb05285.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1990.tb14962.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2000.tb02135.x"},{"key":"e_1_2_1_19_2","first-page":"463","article-title":"Eviprostat, a drug for benign prostatic hyperplasia, ameliorates the urodynamic disturbance in rats with cystitis and with chronic urethral obstruction","volume":"28","author":"Sasaki Y","year":"2000","journal-title":"Jpn Pharmacol Ther"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2008.01999.x"},{"key":"e_1_2_1_21_2","first-page":"299","article-title":"Anti\u2010reactive oxygen species activity and anti\u2010inflammatory activity of Eviprostat, a phytotherapeutic agent for benign prostatic hyperplasia. Relevance to the protective effect on the lower urinary tract dysfunction induced by ischemia\/reperfusion injury","volume":"18","author":"Oka M","year":"2007","journal-title":"Nippon Hainyo Kino Gakkai Shi"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0045(20000615)44:1<19::AID-PROS3>3.0.CO;2-S"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.07.034"},{"key":"e_1_2_1_24_2","first-page":"459","article-title":"Effects of cernitin pollen\u2010extract (Cernilton) on inflammatory cytokines in sex\u2010hormone\u2010induced nonbacterial prostatitis rats","volume":"47","author":"Asakawa K","year":"2001","journal-title":"Hinyokika Kiyo"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00352.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06098.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000133655.71782.14"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.20985","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.20985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T23:24:11Z","timestamp":1699917851000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.20985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":26,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2009,9,15]]}},"alternative-id":["10.1002\/pros.20985"],"URL":"https:\/\/doi.org\/10.1002\/pros.20985","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}