{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:05:51Z","timestamp":1792782351205,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T00:00:00Z","timestamp":1294790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["DL084454"],"award-info":[{"award-number":["DL084454"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Prostatitis is a poorly understood disease and increasing evidence suggests inflammation is involved in other prostatic diseases including prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The ability of pre\u2010activated CD8 T cells to induce prostatitis was examined by adoptive transfer of prostate antigen specific CD8 T cells into POET\u20103 mice or POET\u20103\/Luc\/\n                      <jats:italic>Pten<\/jats:italic>\n                      <jats:sup>\u2212\/+<\/jats:sup>\n                      mice. Characterization of the inflammatory response was determined by examining leukocyte infiltration by histological analysis, flow cytometry and by evaluating cytokine and chemokine levels in prostate tissue. The impact of inflammation on the prostate was evaluated by monitoring epithelial cell proliferation over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Initiation of inflammation by ovalbumin specific CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells (OT\u2010I cells) resulted in development of acute prostatitis in the anterior, dorsolateral and ventral prostate of POET\u20103 and POET\u20103\/Luc\/\n                      <jats:italic>Pten<\/jats:italic>\n                      <jats:sup>\u2212\/+<\/jats:sup>\n                      mice. Acute prostatitis was characterized by recruitment of adoptively transferred OT\u2010I cells and importantly, autologous CD4\n                      <jats:sup>+<\/jats:sup>\n                      and CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells, myeloid\u2010derived suppressor cells (MDSC) and regulatory T cells (Treg). In concert with leukocyte infiltration elevated levels of pro\u2010inflammatory cytokines and chemokines were observed. Inflammation also resulted in marked epithelial cell proliferation that was sustained up to 80 days post adoptive transfer of OT\u2010I cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      The POET\u20103 model represents a novel mouse model to study both acute and chronic prostate inflammation in an antigen\u2010specific system. Further, the POET\u20103 mouse model can be crossed with other genetic models of disease such as the C57\/Luc\/\n                      <jats:italic>Pten<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      model of prostate cancer, allowing the impact of prostatitis on other prostatic diseases to be evaluated. Prostate 71:1139\u20131150, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.21327","type":"journal-article","created":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T11:03:33Z","timestamp":1294830213000},"page":"1139-1150","source":"Crossref","is-referenced-by-count":50,"title":["An inducible model of abacterial prostatitis induces antigen specific inflammatory and proliferative changes in the murine prostate"],"prefix":"10.1002","volume":"71","author":[{"given":"Jessica M.","family":"Haverkamp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Charbonneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Crist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Meyerholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert U.","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsing\u2010Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Ratliff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00456-1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63564-X"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.03.089"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66541-X"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00336-1"},{"issue":"4","key":"e_1_2_6_7_2","first-page":"189","article-title":"Prevalence of prostatitis\u2010like symptoms in Singapore: A population\u2010based study","volume":"43","author":"Tan JK","year":"2002","journal-title":"Singapore Med J"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01636-9"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)02081-2"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000082710.47402.03"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2001.01223.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.06.010"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.3.236"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21536"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2090"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0045(20000915)45:1<1::AID-PROS1>3.0.CO;2-V"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.01.128"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.03.011"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-200403000-00007"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4500930"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1998.0248"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365597909179995"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990050305"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.3.1559"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.1.146"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3088"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00344296"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20307"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02293.x"},{"issue":"6","key":"e_1_2_6_30_2","first-page":"1541","article-title":"Modulation of hypoxia\u2010inducible factor 1alpha expression by the epidermal growth factor\/phosphatidylinositol 3\u2010kinase\/PTEN\/AKT\/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics","volume":"60","author":"Zhong H","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.9.5246"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605370"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.04.013"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-003-0329-0"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00652-X"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(99)00049-0"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251140998"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.10.6098"},{"issue":"1","key":"e_1_2_6_39_2","doi-asserted-by":"crossref","first-page":"472","DOI":"10.4049\/jimmunol.159.1.472","article-title":"Identification of rat prostatic steroid\u2010binding protein as a target antigen of experimental autoimmune prostatitis: Implications for prostate cancer therapy","volume":"159","author":"Liu KJ","year":"1997","journal-title":"J Immunol"},{"issue":"7","key":"e_1_2_6_40_2","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.4049\/jimmunol.159.7.3113","article-title":"Induction of tissue\u2010specific autoimmune prostatitis with prostatic acid phosphatase immunization: Implications for immunotherapy of prostate cancer","volume":"159","author":"Fong L","year":"1997","journal-title":"J Immunol"},{"issue":"7","key":"e_1_2_6_41_2","first-page":"2031","article-title":"An aberrant prostate antigen\u2010specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans","volume":"119","author":"Hou Y","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21027"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.10224"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20061"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21071"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1609"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2506"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.21327","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.21327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.21327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:31:33Z","timestamp":1696926693000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.21327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,12]]},"references-count":47,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1002\/pros.21327"],"URL":"https:\/\/doi.org\/10.1002\/pros.21327","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,12]]}}}