{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:48:49Z","timestamp":1772840929789,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T00:00:00Z","timestamp":1298592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["RO1 CA056678"],"award-info":[{"award-number":["RO1 CA056678"]}]},{"name":"NIH","award":["RO1 CA092579"],"award-info":[{"award-number":["RO1 CA092579"]}]},{"name":"NIH","award":["P50 CA097186"],"award-info":[{"award-number":["P50 CA097186"]}]},{"name":"Fred Hutchinson Cancer Research Center and the Intramural Program of the National Human Genome Research Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Linkage studies have implicated chromosome 1q24 as a putative locus for hereditary prostate cancer. The <jats:italic>RNASEL<\/jats:italic> gene maps to 1q24 and has been associated with prostate cancer risk in multiple family\u2010based linkage studies. The <jats:italic>RNASEL<\/jats:italic> gene product combats viral infection by degrading viral RNA and inducing apoptosis of infected cells. Few studies have evaluated the role of <jats:italic>RNASEL<\/jats:italic> variants in unselected or sporadic prostate cancer, or have considered the potential interaction between <jats:italic>RNASEL<\/jats:italic> variants and patient characteristics associated with past infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Ten SNPs in the <jats:italic>RNASEL<\/jats:italic> gene were genotyped in 1,308 prostate cancer cases and 1,267 age\u2010matched controls from prior population\u2010based, case\u2013control studies. The association between each SNP and haplotype with prostate cancer risk was calculated using logistic regression. Associations stratified by Gleason score were evaluated using polytomous regression. The likelihood ratio test was used to investigate effect modification.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Two <jats:italic>RNASEL<\/jats:italic> SNPs were associated with overall increases in prostate cancer risk (OR\u2009=\u20091.13 for each variant allele of rs12723593; OR\u2009=\u20091.88 for any variant allele of rs56250729). Risk estimates did not vary substantially by Gleason score, but there was effect modification for the variant allele of rs635261 by history of prostatitis (<jats:italic>P<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This study identified three <jats:italic>RNASEL<\/jats:italic> variants that are associated with risk for prostate cancer. Further research is required to confirm these results and to better understand the potential role <jats:italic>RNASEL<\/jats:italic> variants may play in the etiology of sporadic prostate cancer. Prostate 71:1538\u20131547, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.21370","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T16:08:03Z","timestamp":1298736483000},"page":"1538-1547","source":"Crossref","is-referenced-by-count":14,"title":["Genetic variation in <i>RNASEL<\/i> and risk for prostate cancer in a population\u2010based case\u2013control study"],"prefix":"10.1002","volume":"71","author":[{"given":"Megan D.","family":"Fesinmeyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika M.","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine 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