{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:40:40Z","timestamp":1780375240724,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,5,2]],"date-time":"2011-05-02T00:00:00Z","timestamp":1304294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Experimental autoimmune prostatitis (EAP) is an autoimmune inflammatory disease of male sex accessory glands and is characterized by a cellular and humoral prostate\u2010specific autoimmune response. EAP shares important clinical and immunological features with human chronic prostatitis and chronic pelvic pain syndrome. MS\u2010275, a potent histone deacetylase inhibitor, has promising anti\u2010inflammatory activities and might be a new agent in the therapy of prostate inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>EAP rats were treated with MS\u2010275 (5\u2009mg\/kg, i.p.) once daily. Using immunohistochemistry and PCR assay, we determined immune cellular responses and infiltration into the prostate glands, and changes of mRNA levels of representative inflammatory molecules in prostate tissue. Changes in Foxp3<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup> cell populations of lymph nodes and peripheral blood were analyzed by flow cytometry. Additionally, direct anti\u2010inflammatory effects of MS\u2010275 were investigated in vitro with a macrophage cell line.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>MS\u2010275 treatment significantly reduced the local accumulation of immune cells and mRNA levels of representative pro\u2010inflammatory molecules in prostate tissue. Furthermore, MS\u2010275 treatment increased percentage of Foxp3<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup> Treg cells in lymph nodes and their proportion to CD4<jats:sup>+<\/jats:sup> cells in peripheral blood, and induced a relative increase of ED2<jats:sup>+<\/jats:sup> macrophage numbers in EAP prostate. Additional in vitro study showed that MS\u2010275 induced a switch of macrophages from classic M1 to anti\u2010inflammatory M2 phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In summary, our data demonstrated that MS\u2010275 could effectively suppress inflammatory reaction in EAP, through suppressing immune cells and pro\u2010inflammatory molecules, and inducing anti\u2010inflammatory immune cells and molecules, which may suggest MS\u2010275 as a potential candidate for treatment of inflammatory prostatitis. 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