{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:01:44Z","timestamp":1761580904904},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Recently two new methods for prospective studies of adverse effects after treatment have been developed: Proportions of patients regaining 90% of baseline function score (PBS\u201090) and Generalized Estimating Equation (GEE). We compared these methods to examine changes of sexual, urinary, and bowel functions after robot\u2010assisted prostatectomy (RALP) and conformal external beam radiotherapy (EBRT) in patients without androgen deprivation therapy (ADT).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The post\u2010treatment functional course was studied prospectively in 254 patients (N\u2009=\u2009150\u2009RALP and N\u2009=\u2009104\u2009EBRT) with PBS\u201090 and GEE. The time points at which functions reached stability and significant associations with function at 24 months were examined with PBS\u201090, and predictors were identified with GEE. The patients filled in the UCLA\u2010PCI questionnaire at baseline and at 3, 6, 12, and 24\u2010month post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The proportions reaching PBS\u201090 at 24 months were 69% EBRT and 34% RALP patients for urinary function, 70% of EBRT and 7% of RALP patients for sexual function, and 70% of EBRT and 86% of RALP patients for bowel function. GEE showed that the function scores at 6 months were significantly associated with the functions at 24 months. PBS\u201090 found that stability of function was reached at 3 months for urinary and 6 months for sexual and bowel functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In outcome assessment PBS\u201090 mainly demonstrates when post\u2010treatment level become stabilized and GEE shows the time points at which final outcome can be predicted. The two methods therefore supplement each other. Changes of functions corresponded to those reported in samples including patients having ADT. Prostate 72:668\u2013676, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.21470","type":"journal-article","created":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T16:12:02Z","timestamp":1312215122000},"page":"668-676","source":"Crossref","is-referenced-by-count":7,"title":["Methods for prospective studies of adverse effects as applied to prostate cancer patients treated with surgery or radiotherapy without hormones"],"prefix":"10.1002","volume":"72","author":[{"given":"Andreas","family":"Stensvold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alv A.","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f8rn","family":"Brennhovd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milada","family":"Cvancarova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie D.","family":"Foss\u00e5","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Lilleby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karol","family":"Axcrona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigbj\u00f8rn","family":"Smeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/jama.280.11.969","article-title":"Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer","volume":"11","author":"D'Amico AV","year":"1998","journal-title":"JAMA"},{"key":"e_1_2_6_3_2","unstructured":"Association of Urology.Homepage Association of Urology EAU Guidelines. Avilable from:http\/\/www.uroweb.\/org\/. March 2009."},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2010.492236"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa074311"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1001\/jama.1995.03520260051032","article-title":"Quality\u2010of\u2010life outcomes in men treated for localized prostate cancer","volume":"2","author":"Litwin MS","year":"1995","journal-title":"JAMA"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.199"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22676"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.3245"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.102"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1200\/JCO.2005.07.116","article-title":"Long\u2010term outcomes among localized prostate cancer survivors: health\u2010related quality\u2010of\u2010life changes after radical prostatectomy, external radiation, and brachytherapy","volume":"12","author":"Miller DC","year":"2005","journal-title":"J Clin Oncol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.13"},{"key":"e_1_2_6_13_2","volume-title":"Cancer stagning manual","author":"American Joint Committee on Cancer","year":"2002"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65531-0"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199807000-00007"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2007.00745.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067423"},{"issue":"1","key":"e_1_2_6_18_2","first-page":"309","article-title":"Correlates of bother following treatment for clinically localized prostate cancer","volume":"4","author":"Gore JL","year":"2010","journal-title":"J Urol"},{"key":"e_1_2_6_19_2","article-title":"Can sexual bother after radical prostatectomy be predicted pre\u2010operatively?","author":"Steinsvik EA","journal-title":"BJU"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(98)80052-6"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.7305"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.21470","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.21470","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.21470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T13:41:40Z","timestamp":1700574100000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.21470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1002\/pros.21470"],"URL":"https:\/\/doi.org\/10.1002\/pros.21470","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}