{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T04:29:21Z","timestamp":1697689761759},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,12,27]],"date-time":"2011-12-27T00:00:00Z","timestamp":1324944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Urology, University of Pittsburgh and NIH","award":["CA138444","CA111525"],"award-info":[{"award-number":["CA138444","CA111525"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The excision repair cross complementing (<jats:italic>ERCC1<\/jats:italic>) gene product plays a vital role in the nucleotide excision repair (NER) and DNA interstrand crosslink repair pathways, which protect the genome from mutations and chromosomal aberrations, respectively. Genetic deletion of <jats:italic>Ercc1<\/jats:italic> in the mouse causes dramatically accelerated aging. We examined the effect of <jats:italic>Ercc1<\/jats:italic> deletion in the development of prostate cancer in a prostate recapitulation model as <jats:italic>Ercc1<\/jats:italic> deficient mice die within four weeks of birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Prostate tissues from <jats:italic>Ercc1<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice or wild\u2010type littermates were combined with embryonic rat urogenital mesenchyme and grown as renal grafts for a total of 8, 16, and 24 weeks before histological, expression and proliferative evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Invasive adenocarcinoma was observed in <jats:italic>Ercc1<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> tissue recombinants but not wild\u2010type as early as 8 weeks post\u2010grafting. PIN\u2010like lesions in <jats:italic>Ercc1<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> tissue recombinants had more cytologic and architectural atypia than wild\u2010type (<jats:italic>P<\/jats:italic>\u2009=\u20090.02, <jats:italic>P<\/jats:italic>\u2009=\u20090.0065, and <jats:italic>P<\/jats:italic>\u2009=\u20090.0003 at the 8, 16, and 24 weeks, respectively), as well as more proliferative cells (<jats:italic>P<\/jats:italic>\u2009=\u20090.022 and <jats:italic>P<\/jats:italic>\u2009=\u20090.033 at 8 and 16 weeks, respectively). With serial grafting, <jats:italic>Ercc1<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> tissue recombinants progressed to a more severe histopathological phenotype more rapidly than wild\u2010type (<jats:italic>P<\/jats:italic>\u2009=\u20090.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Results show that <jats:italic>ERCC1<\/jats:italic> and by implication the NER and\/or interstrand crosslink repair mechanisms protect against prostate carcinogenesis and mutations or polymorphisms affecting these DNA repair pathways may predispose prostate epithelial cells to transformation. Prostate 72:1214\u20131222, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.22472","type":"journal-article","created":{"date-parts":[[2011,12,27]],"date-time":"2011-12-27T13:45:43Z","timestamp":1324993543000},"page":"1214-1222","source":"Crossref","is-referenced-by-count":5,"title":["Deficiency of DNA repair nuclease ERCC1\u2010XPF promotes prostate cancer progression in a tissue recombination model"],"prefix":"10.1002","volume":"72","author":[{"given":"Derek J.","family":"Matoka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana S.","family":"Harya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Gregg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andria R.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura J.","family":"Niedernhofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil V.","family":"Parwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean J.","family":"Bacich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20073"},{"key":"e_1_2_6_3_2","first-page":"6025","article-title":"Age\u2010related radical\u2010induced DNA damage is linked to prostate cancer","volume":"61","author":"Malins DC","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_4_2","first-page":"514","article-title":"Molecular biology of prostate cancer","volume":"21","author":"Isaacs WB","year":"1994","journal-title":"Semin Oncol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(01)00310-6"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20696"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2703"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-007-9055-z"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4501027"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00690-5"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/0470868716.ch9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1993.tb09233.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1056154"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.08.019"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2670"},{"key":"e_1_2_6_16_2","first-page":"6470","article-title":"Primary cultures of prostate cells and their ability to activate carcinogens","volume":"61","author":"Martin FL","year":"2002","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn067"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.07.001"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.13.5776-5787.2004"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00293-08"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80155-5"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05456"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1193-217"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1983.tb01317.x"},{"key":"e_1_2_6_25_2","first-page":"66","article-title":"Permissive and instructive induction of adult rodent prostatic epithelium by heterotypic urogenital sinus mesenchyme","volume":"2","author":"Hayashi N","year":"1993","journal-title":"Epithelial Cell Biol"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-97-3-665"},{"key":"e_1_2_6_27_2","first-page":"6008","article-title":"Sex hormone\u2010induced carcinogenesis in Rb\u2010deficient prostate tissue","volume":"60","author":"Wang Y","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_6_28_2","first-page":"273","volume-title":"Assessment of current concepts and approaches to the study of prostate cancer","author":"Cunha GR","year":"1987"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2328"},{"key":"e_1_2_6_30_2","first-page":"197","article-title":"DNA repair capacity: Inconsistency between effect of over\u2010expression of five NER genes and the correlation to mRNA levels in primary lymphocytes","volume":"461","author":"Bogel U","year":"2001","journal-title":"Mutat Res"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/35094000"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.10.001"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20032"},{"key":"e_1_2_6_34_2","first-page":"3877","article-title":"Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression","volume":"63","author":"Vanaja DK","year":"2003","journal-title":"Cancer Res"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.22472","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.22472","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.22472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T21:18:08Z","timestamp":1697663888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.22472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,27]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1002\/pros.22472"],"URL":"https:\/\/doi.org\/10.1002\/pros.22472","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,27]]}}}