{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:27:02Z","timestamp":1778570822819,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T00:00:00Z","timestamp":1356912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Roswell Park Alliance Foundation"},{"name":"NCI","award":["CA 016056"],"award-info":[{"award-number":["CA 016056"]}]},{"name":"Department of Defense (DoD) Prostate Cancer Research Program","award":["DAMD 17-03-2-0052"],"award-info":[{"award-number":["DAMD 17-03-2-0052"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Epidemiological studies indicate that calcium channel blocker (CCB) use is inversely related to prostate cancer (PCa) incidence. The association between CCB use and PCa aggressiveness at the time of radical prostatectomy (RP) and outcome after RP was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Medication use, PCa aggressiveness and post\u2010RP outcome were retrieved from a prospectively populated database that contains clinical and outcome for RP patients at Roswell Park Cancer Institute (RPCI) from 1993 to 2010. The database was queried for anti\u2010hypertensive medication use at diagnosis for patients with \u22651 year follow\u2010up. Recurrence was defined using NCCN guidelines. Chi\u2010Square tests assessed the relationship between CCB use and PCa aggressiveness. Cox regression models compared the distribution of progression\u2010free survival (PFS) and overall survival (OS) with adjustment for covariates. Results for association between CCB usage and PCa aggressiveness were validated using data from the population\u2010based North Carolina\u2010Louisiana Prostate Cancer Project (PCaP).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>48%, 37%, and 15% of RPCI's RP patients (n\u2009=\u2009875) had low, intermediate, and high aggressive PCa, respectively. 104 (11%) had a history of CCB use. Patients taking CCBs were more likely to be older, have a higher BMI and use additional anti\u2010hypertensive medications. Diagnostic PSA levels, PCa aggressiveness, and margin status were similar for CCB users and non\u2010users. PFS and OS did not differ between the two groups. Tumor aggressiveness was associated with PFS. CCB use in the PCaP study population was not associated with PCa aggressiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>CCB use is not associated with PCa aggressiveness at diagnosis, PFS or OS. Prostate 73: 865\u2013872, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.22632","type":"journal-article","created":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T20:17:07Z","timestamp":1357071427000},"page":"865-872","source":"Crossref","is-referenced-by-count":16,"title":["The association between calcium channel blocker use and prostate cancer outcome"],"prefix":"10.1002","volume":"73","author":[{"given":"Michael A.","family":"Poch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Mehedint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn J.","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rochelle","family":"Payne\u2010Ondracek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth T.H.","family":"Fontham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannette T.","family":"Bensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristopher","family":"Attwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory E.","family":"Wilding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khurshid A.","family":"Guru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willie","family":"Underwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Mohler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannelore V.","family":"Heemers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,31]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(01)00246-0"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9477-x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2945"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-03-0093"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.10294"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000036152.58271.5e"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9280-0"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(98)00176-9"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-011-9819-3"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.59.6.1376"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0045(20000615)44:1<61::AID-PROS9>3.0.CO;2-3"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(94)90090-6"},{"issue":"2","key":"e_1_2_8_14_2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.6004\/jnccn.2010.0012","article-title":"NCCN clinical practice guidelines in oncology: Prostate cancer","volume":"8","author":"Mohler J","journal-title":"J Natl Compr Canc Netw"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20449"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.10.156"},{"issue":"4","key":"e_1_2_8_17_2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/oxfordjournals.aje.a115543","article-title":"Body mass index versus height and weight in relation to blood pressure. 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