{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:11:13Z","timestamp":1761059473713},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T00:00:00Z","timestamp":1360108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>High dietary intake of soy or selenium (Se) is associated with decreased risk of prostate cancer. Soy constituents and various chemical forms of Se have each been shown to downregulate expression of the androgen receptor (AR) and AR\u2010regulated genes in the prostate. We hypothesized that downregulation of AR and AR\u2010regulated genes by the combination of these dietary components would inhibit tumorigenesis in the TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mouse.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Male mice were exposed from conception to stock diets high or low in soy, with or without a supplement of Se\u2010methylseleno\u2010<jats:sc>L<\/jats:sc>\u2010cysteine (MSC) in a 2\u2009\u00d7\u20092 factorial design. Mice were sacrificed at 18 weeks. Prostate histopathology, urogenital tract (UGT) weight, hepatic activity of androgen\u2010metabolizing enzymes, and expression of AR, AR\u2010regulated, and AR\u2010associated FOX family genes, in the dorsolateral prostate were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>High soy intake decreased activity of hepatic aromatase and 5\u03b1\u2010reductase, expression of AR, AR\u2010regulated genes, FOXA1, UGT weight, and tumor progression, and upregulated protective FOXO3. Supplemental MSC upregulated AKR1C14, which reduces 5\u03b1\u2010dihydrotestosterone.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Soy is an effective pleiotropic dietary agent for prevention of prostate cancer. The finding of effects of soy on FOX family gene expression in animals is novel. Combination effects of supplemental MSC may depend upon the soy content of the basal diet to which it is added. Prostate 73: 986\u2013995, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.22646","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T13:13:38Z","timestamp":1360156418000},"page":"986-995","source":"Crossref","is-referenced-by-count":18,"title":["Combination effects of dietary soy and methylselenocysteine in a mouse model of prostate cancer"],"prefix":"10.1002","volume":"73","author":[{"given":"Merrill J.","family":"Christensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor E.","family":"Quiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather L.","family":"Nakken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin 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