{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:07:48Z","timestamp":1793315268564,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":339,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prostate"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1002\/pros.22891","type":"journal-article","created":{"date-parts":[[2014,9,28]],"date-time":"2014-09-28T03:08:06Z","timestamp":1411873686000},"page":"50-59","source":"Crossref","is-referenced-by-count":44,"title":["Experimental autoimmune prostatitis induces microglial activation in the spinal cord"],"prefix":"10.1002","volume":"75","author":[{"given":"Larry","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Urology; Northwestern University Feinberg School of Medicine; Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Done","sequence":"additional","affiliation":[{"name":"Department of Urology; Northwestern University Feinberg School of Medicine; Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Schaeffer","sequence":"additional","affiliation":[{"name":"Department of Urology; Northwestern University Feinberg School of Medicine; Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-4172","authenticated-orcid":false,"given":"Praveen","family":"Thumbikat","sequence":"additional","affiliation":[{"name":"Department of Urology; Northwestern University Feinberg School of Medicine; Chicago Illinois"},{"name":"Department of Pathology; Northwestern University Feinberg School of Medicine; Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,27]]},"reference":[{"issue":"5 Suppl","key":"10.1002\/pros.22891-BIB0001|pros22891-cit-0001","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1016\/j.juro.2008.03.139","article-title":"Mechanisms in prostatitis\/chronic pelvic pain syndrome","volume":"179","author":"Pontari","year":"2008","journal-title":"J Urol"},{"issue":"2","key":"10.1002\/pros.22891-BIB0002|pros22891-cit-0002","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1128\/IAI.00910-10","article-title":"Uropathogenic Escherichia coli induces chronic pelvic pain","volume":"79","author":"Rudick","year":"2011","journal-title":"Infect Immun"},{"issue":"4","key":"10.1002\/pros.22891-BIB0003|pros22891-cit-0003","doi-asserted-by":"crossref","first-page":"R1268","DOI":"10.1152\/ajpregu.00836.2007","article-title":"Experimental autoimmune prostatitis induces chronic pelvic pain","volume":"294","author":"Rudick","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"4","key":"10.1002\/pros.22891-BIB0004|pros22891-cit-0004","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.juro.2011.11.116","article-title":"Role of mast cells in male chronic pelvic pain","volume":"187","author":"Done","year":"2012","journal-title":"J Urol"},{"issue":"6","key":"10.1002\/pros.22891-BIB0005|pros22891-cit-0005","doi-asserted-by":"crossref","first-page":"R580","DOI":"10.1152\/ajpregu.00240.2012","article-title":"CCL2 and CCL3 are essential mediators of pelvic pain in experimental autoimmune prostatitis","volume":"303","author":"Quick","year":"2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"10.1002\/pros.22891-BIB0006|pros22891-cit-0006","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.coph.2011.10.007","article-title":"Chemokines and cytokines in neuroinflammation leading to neuropathic pain","volume":"12","author":"Kiguchi","year":"2012","journal-title":"Curr Opin Pharmacol"},{"issue":"3","key":"10.1002\/pros.22891-BIB0007|pros22891-cit-0007","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.neuroscience.2007.08.014","article-title":"Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses","volume":"149","author":"Menetski","year":"2007","journal-title":"Neuroscience"},{"issue":"1","key":"10.1002\/pros.22891-BIB0008|pros22891-cit-0008","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2010.07.085","article-title":"CC-chemokine MIP-1alpha in the spinal cord contributes to nerve injury-induced neuropathic pain","volume":"484","author":"Kiguchi","year":"2010","journal-title":"Neurosci Lett"},{"issue":"11","key":"10.1002\/pros.22891-BIB0009|pros22891-cit-0009","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1002\/jnr.23105","article-title":"Neuronal injury induces microglial production of macrophage inflammatory protein-1alpha in rat corticostriatal slice cultures","volume":"90","author":"Okamura","year":"2012","journal-title":"J Neurosci Res"},{"issue":"6950","key":"10.1002\/pros.22891-BIB0010|pros22891-cit-0010","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nature01786","article-title":"P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury","volume":"424","author":"Tsuda","year":"2003","journal-title":"Nature"},{"issue":"11","key":"10.1002\/pros.22891-BIB0011|pros22891-cit-0011","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1523\/JNEUROSCI.5714-08.2009","article-title":"P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation","volume":"29","author":"Trang","year":"2009","journal-title":"J Neurosci"},{"issue":"2","key":"10.1002\/pros.22891-BIB0012|pros22891-cit-0012","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s11302-011-9288-x","article-title":"CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia","volume":"8","author":"Toyomitsu","year":"2012","journal-title":"Purinergic Signal"},{"issue":"2","key":"10.1002\/pros.22891-BIB0013|pros22891-cit-0013","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.pain.2010.02.025","article-title":"Macrophage inflammatory protein-1alpha mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1beta up-regulation","volume":"149","author":"Kiguchi","year":"2010","journal-title":"Pain"},{"issue":"16","key":"10.1002\/pros.22891-BIB0014|pros22891-cit-0014","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1523\/JNEUROSCI.0003-06.2006","article-title":"Activated microglia contribute to the maintenance of chronic pain after spinal cord injury","volume":"26","author":"Hains","year":"2006","journal-title":"J Neurosci"},{"issue":"32","key":"10.1002\/pros.22891-BIB0015|pros22891-cit-0015","doi-asserted-by":"crossref","first-page":"10833","DOI":"10.1523\/JNEUROSCI.5628-11.2012","article-title":"Chronic-pain-associated astrocytic reaction in the spinal cord dorsal horn of human immunodeficiency virus-infected patients","volume":"32","author":"Shi","year":"2012","journal-title":"J Neurosci"},{"issue":"21","key":"10.1002\/pros.22891-BIB0016|pros22891-cit-0016","doi-asserted-by":"crossref","first-page":"7759","DOI":"10.1523\/JNEUROSCI.23-21-07759.2003","article-title":"Increased morphological diversity of microglia in the activated hypothalamic supraoptic nucleus","volume":"23","author":"Ayoub","year":"2003","journal-title":"J Neurosci"},{"issue":"8","key":"10.1002\/pros.22891-BIB0017|pros22891-cit-0017","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/nn.3155","article-title":"P2XR+ microglia drive neuropathic pain","volume":"15","author":"Beggs","year":"2012","journal-title":"Nat Neurosci"},{"issue":"5","key":"10.1002\/pros.22891-BIB0018|pros22891-cit-0018","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3171\/2010.12.SPINE10480","article-title":"Spatiotemporal CCR1, CCL3(MIP-1\u03b1), CXCR4, CXCL12(SDF-1\u03b1) expression patterns in a rat spinal cord injury model of posttraumatic neuropathic pain","volume":"14","author":"Knerlich-Lukoschus","year":"2011","journal-title":"J Neurosurg Spine"},{"key":"10.1002\/pros.22891-BIB0019|pros22891-cit-0019","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1301738","article-title":"CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration","author":"Kohno","year":"2014","journal-title":"J Immunol"},{"issue":"10","key":"10.1002\/pros.22891-BIB0020|pros22891-cit-0020","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1084\/jem.20080421","article-title":"Ly6c+ \u201cinflammatory monocytes\u201d are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis","volume":"205","author":"Getts","year":"2008","journal-title":"J Exp Med"},{"issue":"6","key":"10.1002\/pros.22891-BIB0021|pros22891-cit-0021","doi-asserted-by":"crossref","first-page":"e39897","DOI":"10.1371\/journal.pone.0039897","article-title":"Intrathecal injection of spironolactone attenuates radicular pain by inhibition of spinal microglia activation in a rat model","volume":"7","author":"Sun","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1002\/pros.22891-BIB0022|pros22891-cit-0022","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.bbi.2010.01.014","article-title":"Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis","volume":"24","author":"Murphy","year":"2010","journal-title":"Brain Behav Immun"},{"issue":"1","key":"10.1002\/pros.22891-BIB0023|pros22891-cit-0023","doi-asserted-by":"crossref","first-page":"e87788","DOI":"10.1371\/journal.pone.0087788","article-title":"ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain\/hypersensitivity","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"issue":"1-2","key":"10.1002\/pros.22891-BIB0024|pros22891-cit-0024","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pain.2004.12.022","article-title":"ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model","volume":"114","author":"Zhuang","year":"2005","journal-title":"Pain"},{"issue":"3","key":"10.1002\/pros.22891-BIB0025|pros22891-cit-0025","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.pain.2005.12.023","article-title":"Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury","volume":"121","author":"Piao","year":"2006","journal-title":"Pain"},{"key":"10.1002\/pros.22891-BIB0026|pros22891-cit-0026","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuroscience.2012.06.024","article-title":"Minocycline blocks lipopolysaccharide induced hyperalgesia by suppression of microglia but not astrocytes","volume":"221","author":"Yoon","year":"2012","journal-title":"Neuroscience"},{"issue":"4","key":"10.1002\/pros.22891-BIB0027|pros22891-cit-0027","doi-asserted-by":"crossref","first-page":"e60987","DOI":"10.1371\/journal.pone.0060987","article-title":"Th1-Th17 cells contribute to the development of uropathogenic Escherichia coli-induced chronic pelvic pain","volume":"8","author":"Quick","year":"2013","journal-title":"PLoS One"},{"key":"10.1002\/pros.22891-BIB0028|pros22891-cit-0028","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neulet.2013.08.062","article-title":"Up-regulation of spinal microglial Iba-1 expression persists after resolution of neuropathic pain hypersensitivity","volume":"554","author":"Leinders","year":"2013","journal-title":"Neurosci Lett"},{"issue":"17","key":"10.1002\/pros.22891-BIB0029|pros22891-cit-0029","doi-asserted-by":"crossref","first-page":"6522","DOI":"10.1523\/JNEUROSCI.17-17-06522.1997","article-title":"Murine astrocytes express a functional chemokine receptor","volume":"17","author":"Tanabe","year":"1997","journal-title":"J Neurosci"},{"issue":"3","key":"10.1002\/pros.22891-BIB0030|pros22891-cit-0030","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/glia.20117","article-title":"Differential activation of astrocytes by innate and adaptive immune stimuli","volume":"49","author":"Carpentier","year":"2005","journal-title":"Glia"},{"issue":"1-2","key":"10.1002\/pros.22891-BIB0031|pros22891-cit-0031","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0165-5728(00)00274-5","article-title":"Expression of the \u03b2-chemokine receptors CCR2, CCR3 and CCR5 in multiple sclerosis central nervous system tissue","volume":"108","author":"Simpson","year":"2000","journal-title":"J Neuroimmunol"},{"issue":"12","key":"10.1002\/pros.22891-BIB0032|pros22891-cit-0032","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1073\/pnas.0406030102","article-title":"A proinflammatory chemokine, CCL3, sensitizes the heat-, capsaicin-gated ion channel TRPV1","volume":"102","author":"Zhang","year":"2005","journal-title":"Proc Natl Acad Sci U.S.A."},{"issue":"1","key":"10.1002\/pros.22891-BIB0033|pros22891-cit-0033","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1471-4159.2007.04969.x","article-title":"Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons","volume":"104","author":"Jung","year":"2008","journal-title":"J Neurochem"},{"issue":"3","key":"10.1002\/pros.22891-BIB0034|pros22891-cit-0034","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ejpain.2008.04.017","article-title":"CCL2 is a key mediator of microglia activation in neuropathic pain states","volume":"13","author":"Thacker","year":"2009","journal-title":"Eur J Pain"},{"issue":"1","key":"10.1002\/pros.22891-BIB0035|pros22891-cit-0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrn3617","article-title":"Neurogenic neuroinflammation: Inflammatory CNS reactions in response to neuronal activity","volume":"15","author":"Xanthos","year":"2014","journal-title":"Nat Rev Neurosci"},{"issue":"7","key":"10.1002\/pros.22891-BIB0036|pros22891-cit-0036","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1152\/jn.01088.2012","article-title":"Dynamic effects of TNF-\u03b1 on synaptic transmission in mice over time following sciatic nerve chronic constriction injury","volume":"110","author":"Zhang","year":"2013","journal-title":"J Neurophysiol"},{"issue":"10","key":"10.1002\/pros.22891-BIB0037|pros22891-cit-0037","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.pain.2013.07.002","article-title":"Chemokine contribution to neuropathic pain: Respective induction of CXCL1, CXCR2 in spinal cord astrocytes, neurons","volume":"154","author":"Zhang","year":"2013","journal-title":"PAIN"},{"key":"10.1002\/pros.22891-BIB0038|pros22891-cit-0038","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jaut.2012.11.003","article-title":"Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE","volume":"42","author":"Christy","year":"2013","journal-title":"J Autoimmun"},{"key":"10.1002\/pros.22891-BIB0039|pros22891-cit-0039","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bbi.2013.07.174","article-title":"Classical activation of microglia in CD200-deficient mice is a consequence of blood brain barrier permeability and infiltration of peripheral cells","volume":"34","author":"Denieffe","year":"2013","journal-title":"Brain Behav Immun"},{"issue":"30","key":"10.1002\/pros.22891-BIB0040|pros22891-cit-0040","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1523\/JNEUROSCI.1642-11.2011","article-title":"Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway","volume":"31","author":"Echeverry","year":"2011","journal-title":"J Neurosci"},{"issue":"2","key":"10.1002\/pros.22891-BIB0041|pros22891-cit-0041","doi-asserted-by":"crossref","first-page":"e56586","DOI":"10.1371\/journal.pone.0056586","article-title":"Imatinib ameliorates neuroinflammation in a rat model of multiple sclerosis by enhancing blood-brain barrier integrity, by modulating the peripheral immune response","volume":"8","author":"Adzemovic","year":"2013","journal-title":"PLoS ONE"},{"issue":"43","key":"10.1002\/pros.22891-BIB0042|pros22891-cit-0042","doi-asserted-by":"crossref","first-page":"13435","DOI":"10.1523\/JNEUROSCI.3257-09.2009","article-title":"Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord","volume":"29","author":"Kigerl","year":"2009","journal-title":"J Neurosci"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.22891","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/pros.22891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T03:55:02Z","timestamp":1717386902000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.22891"}},"subtitle":["Neuroinflammation and Microglial Activation in Prostatitis"],"short-title":[],"issued":{"date-parts":[[2014,9,27]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"URL":"https:\/\/doi.org\/10.1002\/pros.22891","relation":{},"ISSN":["0270-4137"],"issn-type":[{"value":"0270-4137","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9,27]]}}}